Science
Mechanism of Action
This extract functions by potent antioxidant action, neutralizing free radicals to shield skin cells from oxidative stress and mitigate signs of aging. It exerts anti-inflammatory effects by inhibiting nitric oxide production in macrophage cells. Its antimicrobial properties target common skin pathogens, supporting skin health and wound healing. Additionally, it acts as an astringent to refine pores and manage excess oil, conditions the skin, potentially brightens through anti-tyrosinase activity, enhances collagen synthesis, and offers some UV protection.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Maintained HaCaT cell viability up to 98% at 400 µg/mL.
- 02 Showed over 40% bacterial mortality rate against Proteus vulgaris in HaCaT cells at 200 µg/mL.
- 03 Exhibited significant antibacterial activity against Staphylococcus lugdunensis and Staphylococcus aureus with a Minimum Inhibitory Concentration (MIC) of 2-4 mg/mL.
- 04 Inhibited 50% of nitric oxide (NO) production by macrophage cells, demonstrating anti-inflammatory effects, at 109 ± 5 µg/mL.
- 05 Demonstrated antioxidant activity (DPPH assay) with an EC50 of 137 ± 10 µg/mL.
- 06 Showed reducing power with an EC50 of 27.6 ± 0.02 µg/mL.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The extract demonstrates good physicochemical stability and maintains antioxidant efficacy when incorporated into oil-in-water base creams under various storage conditions. Optimal chemical stability is observed around a neutral pH of 6.01. Juglone, a component of the extract, is stable in acidic conditions but may degrade in certain solvents and aquatic environments.
Safety
Safety Profile
While the aqueous extract is free from essential oils and declarable fragrance allergens, juglone, a compound naturally present in walnut, has been rarely reported to cause skin irritation and hyperpigmentation in humans. Further comprehensive toxicological studies, including skin and eye irritation, genotoxicity, and photo-irritation assessments, are recommended for a full regulatory evaluation.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Juglans Regia Leaf Extract is a valuable botanical offering robust antioxidant, anti-inflammatory, and antimicrobial benefits, making it highly effective for diverse skin concerns, though specific juglone considerations warrant cautious formulation.
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