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Moumoujus

JUGLANS NIGRA SHELL EXTRACT.

Questionable CAS 96690-56-1 / ASTRINGENT, FRAGRANCE, SKIN CONDITIONING - EMOLLIENT

Juglans Nigra Shell Extract, derived from black walnuts, is recognized for its multifaceted properties, including astringent, antioxidant, and anti-inflammatory effects. This extract also offers antimicrobial benefits and can act as an emollient, though its usage necessitates careful consideration due to potential irritancy and allergenicity.

Summary

astringent emollient masking antiseptic antioxidant anti-inflammatory antimicrobial antifungal exfoliating (as abrasive powder) skin rejuvenation

Science

Mechanism of Action

This extract functions as an astringent by contracting and tightening skin, primarily due to its tannin content. Its antioxidant capabilities help neutralize free radicals, potentially mitigating signs of aging. Antiseptic, antimicrobial, and antifungal actions are attributed to compounds like juglone and tannins. In vitro studies have demonstrated its capacity to inhibit the secretion of various proinflammatory cytokines (e.g., IL-6, IL-8) in stimulated immune cells, suggesting an anti-inflammatory pathway potentially involving interference with LPS-receptor interactions. Juglone, however, is also responsible for potential skin irritation and temporary dark staining.

Research

Clinical Evidence

Low confidence
Effective range 0.1–10%
Optimal

N/A

Key findings

  1. 01 In an in vitro study, methanolic kernel extracts of black walnut (Juglans nigra) at concentrations up to 10 mg/ml significantly reduced the secretion of proinflammatory cytokines (TNF-α, IL-1β, IL-6, IL-8, IL-10, MCP-1) in LPS-stimulated human promonocytic U-937 cells. Specifically, certain cultivars at 10 mg/ml reduced IL-8 by 26.3% and IL-10 by 22.8%, while IL-6 was reduced by 19.5% to 44.1%.

Transparency

Dusting Analysis

Not commonly dusted

Despite observed in vitro benefits, the significant safety concerns regarding irritation, staining, and allergenicity associated with Juglans Nigra Shell Extract suggest it is not an ingredient commonly 'dusted' at high concentrations without careful consideration. Its diverse chemical profile, particularly the presence of juglone, warrants precise formulation rather than high-percentage inclusion for perceived efficacy.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Juglone, a key active component, is highly stable in acidic conditions but degrades rapidly in alkaline environments, exhibiting a half-life of 18 hours at pH 9.0. Formulations should ideally maintain an acidic pH to ensure the stability and efficacy of the extract.

Conflicts

  • Alkaline environments (due to juglone degradation)
  • Strong abrasives (if used in powder form, due to potential for micro-tears)
  • Products for individuals with nut allergies

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

Black walnuts are classified by the FDA as a tree nut, a common food allergen. Topical application is considered potentially unsafe due to the presence of juglone, a chemical known to cause irritant reactions, including pain, itching, and severe blistering, as well as temporary dark staining of the skin for several weeks. When used in powder form, the abrasive nature of walnut shells may cause irritation or micro-tears. Individuals with nut allergies should exercise extreme caution, and patch testing is highly advisable, particularly for sensitive skin types.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

While exhibiting potential antioxidant, anti-inflammatory, and astringent benefits, the significant risks of irritation, skin staining, and allergenicity associated with Juglans Nigra Shell Extract, primarily due to juglone, render its widespread use in precision skincare questionable.

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