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Moumoujus

JUGLANS NIGRA LEAF EXTRACT.

Valuable CAS 96690-56-1 / ASTRINGENT

Juglans Nigra Leaf Extract, derived from the black walnut tree, is a versatile botanical offering comprehensive benefits for skin health. It provides robust antioxidant protection, while its antimicrobial and anti-inflammatory properties are beneficial for addressing various skin concerns, including blemishes and irritation. Additionally, this extract supports skin regeneration, hydration, and offers an astringent effect for a refined complexion.

Summary

Antioxidant Antimicrobial Anti-inflammatory Skin Conditioning Astringent Moisturizing Skin Regenerating UV Protection Anti-Aging Wound Healing

Science

Mechanism of Action

Juglans Nigra Leaf Extract operates through a rich composition of bioactive compounds, including flavonoids, tannins, vitamins, and juglone. These constituents collectively confer strong antioxidant effects, neutralizing free radicals and helping to protect against visible signs of aging. The extract aids in reducing skin inflammation and exhibits antimicrobial properties, which can be beneficial in managing acne and other skin infections. Furthermore, it promotes skin regeneration and revitalization, provides moisturizing and softening effects, and its tannin content contributes astringent and detergent properties, helping to tighten and tone skin while calming irritation.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In in-vitro cytotoxicity assays, HaCaT cell viability was maintained up to 98% at an extract concentration of 400 µg/mL.
  2. 02 At a concentration of 200 µg/mL, the extract demonstrated over 40% bacterial mortality against Proteus vulgaris in infected HaCaT cells.
  3. 03 In vitro and in vivo studies indicate broad bioactivities including antioxidant, antimicrobial, anti-inflammatory, UV-protective, and wound healing properties, as well as potential for anti-aging, skin hydration, and anti-tyrosinase effects. However, specific optimal concentrations for human topical application have not yet been established through robust human clinical trials.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

A cosmetic cream formulated with Juglans regia leaf extract exhibited favorable physicochemical stability across various storage conditions, successfully retaining its antioxidant efficacy over time. The extract, often prepared through cold maceration, maintains a broad spectrum of beneficial compounds, indicating its suitability for stable topical applications.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

The Cosmetic Ingredient Review (CIR) has not explicitly reviewed Juglans Nigra Leaf Extract. The black walnut plant contains juglone, which may cause topical irritation or allergic reactions in sensitive individuals, as indicated by its 'medium' irritancy rating on Incidecoder. Despite this, the Environmental Working Group (EWG) rates the extract as a '1' (low hazard), with low concerns for cancer, allergies, immunotoxicity, and reproductive toxicity, though it is restricted in EWG VERIFIED products without further substantiation. It is important to note that the extract, sourced from the leaf, is generally not considered an allergen for those with nut allergies.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Medium
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Juglans Nigra Leaf Extract is a valuable botanical offering extensive skin benefits including antioxidant, antimicrobial, and regenerative properties, suitable for diverse skin types and concerns, though further human clinical dosing data would enhance its precise application.

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