Science
Mechanism of Action
Jasminum Sambac Flower Extract acts as a robust antioxidant by directly scavenging free radicals and chelating metal ions, further activating the Nrf2/ARE pathway for enhanced cellular defense. Its skin-lightening properties are attributed to the inhibition of tyrosinase, the enzyme central to melanin production. For anti-aging, it actively promotes collagen type I synthesis, reduces the formation of advanced glycation end products (AGEs), and prevents collagen degradation by reversing p-smad2/3 inactivation. Additionally, its flavonoid and essential oil content provides anti-inflammatory and antibacterial benefits, while also enhancing microcirculation to support skin repair.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 A 2:8 mixture of SFE and RO extracts demonstrated strong antioxidant activity (IC50: 273–421 mg/L) with over 91.3% radical scavenging at concentrations ranging from 0.027% to 0.042%.
- 02 An RO extract exhibited significant antityrosinase activity, with an IC50 of 263.5 mg/L at 0.026%, and a 2:8 mixture of SFE and RO extracts achieved 100% antityrosinase activity.
- 03 Fermented Jasminum sambac flower extracts enhanced HS68 cell viability and mitigated UVB/H2O2-induced reactive oxygen species, collagen degradation, MAPK activation, and premature senescence, also reversing p-smad2/3 inactivation and boosting HO-1/Nrf2 expression for robust anti-aging and collagen-promoting effects.
- 04 Studies indicate increased collagen type I production and a reduction in Advanced Glycation End-product (AGE) formation, reinforcing its anti-aging properties.
- 05 Non-significant cytotoxicity was observed on human CCD-966SK and HEMn cells (cell viability >98.2%) at concentrations up to 0.1%, with only slight cytotoxicity noted at 0.2% to 0.4% for RO extract.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Optimal stability is suggested within a pH range of 6.5 to 6.8. To preserve its desirable aromatic compounds, the ingredient should be stored and formulated away from excessive heat, with 35°C considered ideal and degradation, potentially leading to a 'burnt' smell, occurring above 40°C. Dissolving in Ethoxydiglycol is recommended for formulation.
Conflicts
- High heat (above 40°C)
- Strong oxidizing agents
Safety
Safety Profile
Jasminum Sambac Flower extracts are generally considered safe for use in cosmetics, foods, and medicines, demonstrating high systemic safety (oral LD50 > 5,000 mg/kg BW in Wistar rats). However, due to its volatile fragrance components (e.g., linalool, geraniol, benzyl acetate), it poses a moderate risk for skin irritation and sensitization, particularly in individuals with sensitive skin. The International Fragrance Association (IFRA) sets restriction limits in finished products, such as 0.25% for lip products and 1.33% for face/body products, to mitigate these sensitization concerns.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Jasminum Sambac Flower is a valuable ingredient for its proven antioxidant, anti-aging, and brightening properties, but should be formulated with caution due to a moderate sensitization risk, especially for individuals with sensitive skin.
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