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Moumoujus

JACARANDA CAUCANA LEAF EXTRACT.

Avoid / ANTIMICROBIAL, ANTIOXIDANT

Jacaranda Caucana Leaf Extract is noted for its potential antimicrobial and antioxidant properties, attributed to a rich profile of secondary metabolites. However, its primary constituent, jacaranone, has been linked to significant cytotoxic activity and high cutaneous toxicity, necessitating extreme caution in any application.

Summary

Antimicrobial Antioxidant

Science

Mechanism of Action

This extract primarily functions through its diverse secondary metabolites, including phenylethanoid glycosides, flavonoids, quinones, phytosterols, and anthocyanidins, which contribute to its observed antioxidant and radical-scavenging activities. The quinonoid compound jacaranone specifically contributes to the cytotoxic effects reported for the plant.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Phytochemical investigations have identified cytotoxic activities in Jacaranda caucana, primarily due to the presence of jacaranone.
  2. 02 In-vitro assays, such as the DPPH assay, have demonstrated antioxidant and radical-scavenging activities in Jacaranda caucana stem extract, though an effective concentration (EC50) was not specified.

Transparency

Dusting Analysis

Not commonly dusted

Due to the reported high cutaneous toxicity associated with jacaranone, a key component, formulations must exercise extreme caution. There is no established safe 'red flag' percentage for underdosing; rather, the concern is preventing any concentration that may induce toxicity.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

No specific optimal pH range for stability has been identified through available research.

Conflicts

  • The significant cutaneous toxicity of jacaranone mandates critical and precise concentration control during formulation to mitigate adverse reactions.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

Jacaranone, a constituent of Jacaranda caucana, has been associated with high cutaneous toxicity. The extract lacks specific safety evaluations from regulatory bodies such as CIR, SCCS, or FDA.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Given the documented high cutaneous toxicity of its key component, jacaranone, and the absence of established safe concentration limits or comprehensive regulatory review, this ingredient is not recommended for skincare formulations.

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