Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

ISOSTEARAMIDOPROPYL MORPHOLINE.

Insufficient Data CAS 72300-23-3 / ANTISTATIC

Isostearamidopropyl Morpholine is a cationic surfactant primarily valued for its antistatic and conditioning properties, predominantly in hair care. It functions by modifying electrical charges and imparting a smooth feel, with an additional role as a potential skin permeation enhancer.

Summary

Antistatic Hair conditioning Skin barrier enhancement (permeation)

Science

Mechanism of Action

This ingredient acts as a cationic surfactant, effectively neutralizing static electrical charges on surfaces to provide antistatic benefits. Its hydrophobic isostearic chain allows it to coat hair strands, leading to conditioning effects, while the morpholine group enhances compatibility within formulations. Furthermore, as a morpholine derivative, it may reduce skin barrier function, thereby acting as a transdermal permeation enhancer.

Research

Clinical Evidence

Medium confidence
Effective range 1–5%
Optimal

N/A

Key findings

  1. 01 In repeated-insult patch tests involving 99 subjects, concentrations of 3-4% of Isostearamidopropyl Morpholine did not induce sensitization, though irritation from the shampoo's detergent base was noted.
  2. 02 A human study with 19 volunteers evaluating a shampoo containing 2% Isostearamidopropyl Morpholine Lactate resulted in an average irritancy score of 4.58, observing erythema, scaling, and fissuring.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

This ingredient exhibits resistance to hydrolysis under typical cosmetic formulation conditions.

Synergies

  • Morpholine group enhances compatibility with other formulation ingredients.

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
5%
Sensitization risk Low

The CIR Expert Panel concluded that Isostearamidopropyl Morpholine Lactate is safe for use in rinse-off cosmetic products at current concentrations. However, data are insufficient to determine its safety for leave-on cosmetic formulations, necessitating further studies on skin penetration, dermal toxicity, reproductive/developmental toxicity, mammalian genotoxicity, and inhalation toxicity. No N-nitroso impurities were detected. While minimally irritating to eyes and mildly irritating to intact and abraded skin, sensitization was not observed in clinical tests.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While deemed safe for rinse-off applications up to 5%, the absence of comprehensive safety data for leave-on formulations makes its utility in precision skincare currently uncertain.

Related

Similar Ingredients

Finding similar ingredients…