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ISOPROPYLIDENEGLYCEROL.

Questionable CAS 100-79-8

Isopropylideneglycerol is a functional organic compound employed in skincare for its dual role as a humectant and a solvent. It enhances skin hydration by attracting moisture and aids in improving the solubility and stability of active ingredients within formulations.

Solvent Humectant

Science

On the skin, Isopropylideneglycerol functions as an effective humectant, drawing and retaining water from the environment to augment epidermal moisture content and overall skin hydration. Concurrently, its solvent capabilities facilitate the improved dispersion and stability of other active compounds, thereby optimizing their integration and efficacy in cosmetic formulations.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Both
Optimal pH 4 – 7.5
0 7 14

Stability

The compound maintains chemical stability under typical ambient conditions at room temperature. However, prolonged or strong heating should be avoided to prevent degradation.

Conflicts

  • Reacts with strong oxidants.
  • Forms potentially explosive mixtures with air upon intense heating.

Safety

CIR Status
Not reviewed
Sensitization risk Moderate

While generally considered to have low systemic toxicity, Isopropylideneglycerol poses a moderate risk for topical irritation. It is known to cause serious eye irritation, skin irritation, and has the potential to induce an allergic skin reaction. Ingesting the substance is harmful and may lead to central nervous system effects, including lowered consciousness.


Your Skin

No Normal
Yes Dry
No Oily
No Sensitive
Irritancy Medium
Comedogenicity Unknown

Our Assessment

Questionable

Despite its utility as a humectant and solvent within the optimal pH range of 4.0-7.5, Isopropylideneglycerol’s moderate irritation potential and lack of CIR safety review make its integration into precision skincare formulations questionable without further comprehensive assessment.


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