Science
Mechanism of Action
This ingredient operates as a film-forming polymer, depositing a cohesive and continuous film when applied to skin, hair, or nails.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
ISOPROPYLIDENEDIPHENYL BISOXYHYDROXYPROPYL METHACRYLATE is considered a human skin toxicant and allergen with strong evidence, causing sensitization, irritation, and serious eye irritation upon contact. The Cosmetic Ingredient Review (CIR) Expert Panel has restricted its use in products intended for skin contact, effectively advising a maximum concentration of 0% for such applications. Therefore, its inclusion in any skincare formulation designed for direct dermal application would be inappropriate and potentially harmful.
The Formula
Formulation
Stability
Exhibits very low water solubility, measured at approximately 3 mg/L at 37 °C, and is typically soluble in organic solvents, consistent with its primary use in nail enhancement formulations.
Safety
Safety Profile
The CIR Expert Panel deems this ingredient safe only when used in nail enhancement products and explicitly labeled to prevent skin contact. It is categorized as a human skin toxicant and allergen due to its significant sensitizing potential, capable of inducing sensitization, skin irritation, and severe eye irritation. Cross-reactivity with other methacrylate esters has been observed in sensitization tests.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This ingredient should be strictly avoided in skincare formulations intended for direct skin contact due to its high potential for sensitization and irritation, as evidenced by its 0% maximum concentration restriction by the CIR Expert Panel.
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