Science
Mechanism of Action
This ingredient functions as a selective agonist of the prostaglandin F₂α (FP) receptor, initiating G-protein–coupled signaling pathways that lead to an elevation of intracellular calcium. This molecular action is believed to stimulate hair follicles, promoting new hair growth and extending the anagen (active growth) phase of the hair life cycle, particularly beneficial for lash proliferation.
Research
Clinical Evidence
High confidence0.005%
Key findings
- 01 An 8-month, 120-subject clinical investigation using 0.0044% Isopropyl Cloprostenate in a lash serum demonstrated general safety, a low potential for transient ophthalmological irritation, no statistically significant alteration in visible iris color, and no change in periorbital volume.
- 02 An Intraocular Pressure Assay conducted on a lash serum containing 0.005% Isopropyl Cloprostenate revealed no statistically significant difference in intraocular pressure after 28 days of use.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Isopropyl Cloprostenate exhibits stability for several weeks during typical shipping conditions. For short-term storage (days to weeks), optimal conditions include dry, dark environments at 0-4°C. Long-term preservation (months to years) necessitates storage at -20°C.
Safety
Safety Profile
The CIR Expert Panel supports the safe use of Isopropyl Cloprostenate in cosmetic lash serums at concentrations up to 0.005%, noting a minimal risk of systemic toxicity. However, the SCCS (Scientific Committee on Consumer Safety) was unable to conclude on its safety at higher intended concentrations (0.006%-0.007%) due to insufficient data, raising significant concerns regarding its potent pharmacological activity, potential for carcinogenicity via non-genotoxic mechanisms, reproductive/developmental toxicity, and skin sensitization effects. Furthermore, the FDA considers cosmetic products containing prostaglandin analogues that make growth claims to be unapproved drugs.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While studies indicate efficacy for lash growth at concentrations up to 0.005% and the CIR panel deems it safe under specific restrictions, significant regulatory concerns from the SCCS and FDA regarding its potent pharmacological activity and potential adverse effects render its use highly questionable for a precision skincare brand.
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