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Moumoujus

ISOMERIZED SAFFLOWER ACID.

Valuable CAS 121250-47-3 / ORAL CARE, SKIN CONDITIONING

Isomerized Safflower Acid is a precision skin conditioning agent, derived from linoleic-rich safflower oil. It is formulated to deeply hydrate, fortify the skin barrier, and provide robust antioxidant defense, effectively mitigating visible signs of aging and oxidative stress.

Summary

Skin conditioning Hydrating Anti-inflammatory Antioxidant Barrier repair Anti-aging

Science

Mechanism of Action

Functioning as a conjugated linoleic acid, Isomerized Safflower Acid’s efficacy is rooted in its precursor, linoleic acid. It actively promotes epidermal hydration, reduces transepidermal water loss (TEWL), and strengthens the skin barrier by stimulating the crucial synthesis of ceramides. This ingredient also contributes to anti-inflammatory pathways by converting to gamma-linolenic acid (GLA) and offers significant antioxidant protection, attributed to phytosterols and Vitamin E, which inhibit pro-inflammatory factors and reduce collagenase activity.

Research

Clinical Evidence

High confidence
Effective range 10–15%
Optimal

Studies indicate strong efficacy between 10% and 15%.

Key findings

  1. 01 Safflower cream demonstrated notable antioxidant effects, provided protection against oxidative damage following sunburn, and reduced visible signs of skin aging with an 85% response rate within 2 weeks.
  2. 02 Safflower cream exhibited enhanced antioxidant properties, protected skin from oxidative damage post-sun exposure, and improved symptoms of skin aging with an impressive 92% response rate within 2 weeks.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Similar to its precursor, safflower oil, Isomerized Safflower Acid is highly susceptible to oxidation. Oxidized material may exhibit undesirable changes in texture, color, and odor, and could potentially become comedogenic. For optimal stability, store in a cool, dark environment.

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

The CIR Expert Panel has concluded that plant-derived fatty acid oils, including safflower oil (its source), are safe for use in cosmetic formulations. A dietary study in rats specifically for Isomerized Safflower Acid showed no clinical signs of toxicity at 1% in feed. It is important to note that the FDA's GRAS determination for Conjugated Linoleic Acid (CLA) applies specifically to its methyl esters, not the free acid form typically used topically.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Isomerized Safflower Acid is a valuable ingredient for enhancing skin hydration, reinforcing barrier function, and delivering significant antioxidant and anti-aging benefits, particularly suitable for dry and normal skin types.

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