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Moumoujus

ISOLEUCINE.

Valuable CAS 73-32-5 / 443-79-8 / ANTISTATIC, HAIR CONDITIONING, SKIN CONDITIONING

Isoleucine is an essential amino acid crucial for maintaining skin integrity and function. It acts as a skin-identical ingredient, fortifying the skin's protective barrier, enhancing hydration, and promoting overall skin elasticity and repair.

Summary

Skin conditioning Skin-identical ingredient Moisturizer Barrier repair ingredient Antistatic Hair conditioning Supports protein synthesis Stimulates collagen production Promotes cell renewal Reduces inflammation Protects against oxidative damage

Science

Mechanism of Action

This amino acid plays a pivotal role in protein synthesis, which underpins the skin's structural resilience and its capacity to resist external irritants. Isoleucine actively moisturizes, sustains skin elasticity, and stimulates the growth and regeneration of new skin cells. It contributes to collagen production, reduces inflammation, and offers protection against oxidative damage, thereby enhancing skin repair, elasticity, and vibrancy while helping to initiate surface repair.

Research

Clinical Evidence

High confidence
Effective range 0.0003–0.002%
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Isoleucine is effective even at remarkably low concentrations (0.0003-0.002%) for general skin benefits. This indicates that substantial positive effects can be achieved without the need for high percentages, suggesting it performs efficiently within its active range rather than being 'dusted' at ineffective levels.

The Formula

Formulation

Solubility
Water
Optimal pH 5.5 – 7
0 7 14

Stability

Isoleucine is water-soluble, thus it should be incorporated into the aqueous phase of formulations. To maintain its stability, processing temperatures should be kept below 60°C. General skincare product pH is optimally maintained between 4.5-6.5 for stability and skin barrier compatibility.

Synergies

  • Ceramides
  • Rhamnosoft
  • Copper
  • Hyaluronic Acid

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that isoleucine and its simple salts are safe for cosmetic use at current concentrations. Dermal data indicates they are neither irritants nor sensitizers. Concentrations in cosmetic products are significantly lower than levels that would lead to notable exposure. Additionally, the FDA lists amino acids, including isoleucine, as food additives permitted for direct inclusion in food.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Isoleucine is a valuable skin-identical amino acid that significantly supports barrier health, enhances hydration, improves elasticity, and aids in skin repair and regeneration across all skin types.

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