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Moumoujus

ISODON INFLEXUS BRANCH/LEAF EXTRACT.

Insufficient Data CAS - / BLEACHING

ISODON INFLEXUS BRANCH/LEAF EXTRACT is a botanical ingredient derived from the Isodon inflexus plant, notably rich in bioactive kaurane and abietane diterpenoids. Research indicates its potent in vitro anti-inflammatory and antioxidant capabilities, primarily achieved by modulating cellular inflammatory responses and effectively neutralizing free radicals. It also demonstrates potential in supporting skin brightening efforts.

Summary

Anti-inflammatory Antioxidant Skin conditioning Skin brightening Masking

Science

Mechanism of Action

This extract operates through a multifaceted mechanism on the skin. It actively inhibits nitric oxide (NO) production, a key inflammatory mediator, and suppresses the activation of crucial signaling pathways such as NF-κB and MAPK. In a dose-dependent manner, it reduces the expression of pro-inflammatory proteins including iNOS, COX-2, TNF-α, IL-6, and IL-1β. Additionally, it exhibits antioxidant activity by effectively scavenging superoxide radicals. Specific compounds found within the extract, such as oridonin and nodosin, have also demonstrated an ability to inhibit melanogenesis.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Isolated diterpenoids from Isodon inflexus demonstrated strong inhibitory activity against nitric oxide (NO) production in RAW264.7 lipopolysaccharide (LPS)-activated macrophages at concentrations between 1.0 and 26.5 μM.
  2. 02 Isolated kaurane diterpenoids exhibited inhibitory effects on TNF-α-induced NF-κB activation at concentrations ranging from 1.91 to 20.15 μM.
  3. 03 The full extract displayed dose-dependent anti-inflammatory effects in LPS-induced RAW264.7 cells, decreasing NO production and the expression of inflammatory proteins without observed cytotoxicity at concentrations from 12.5 to 100 μg/ml.
  4. 04 Ethyl acetate and butanol fractions demonstrated significant antioxidant activity via superoxide radical scavenging, with IC50 values of 0.9 μg/mL and 0.2 μg/mL, respectively. These fractions also showed strong NO inhibition and dose-dependent suppression of iNOS, COX-2, TNF-α, IL-6, and IL-1β mRNA expression in RAW 264.7 cells.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The ingredient 'ISODON INFLEXUS BRANCH/LEAF EXTRACT' has not been specifically reviewed for safety in cosmetic applications by prominent regulatory bodies such as the Cosmetic Ingredient Review (CIR), Scientific Committee on Consumer Safety (SCCS), or the FDA. While generally described as non-irritating, generic statements for unrated ingredients suggest a potential for irritation, inflammation, or dryness, particularly when combined with other potentially problematic ingredients.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While showcasing promising in vitro anti-inflammatory, antioxidant, and potential brightening effects, comprehensive safety assessments and in vivo human clinical trials are necessary to establish its definitive role and optimal concentration in precision skincare formulations.

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