Science
Mechanism of Action
This multi-talented microalgae extract revitalizes skin through a rich composition of lipids, proteins, vitamins, and minerals, stimulating cell renewal and blood circulation. Its potent antioxidant activity, primarily from fucoxanthin, neutralizes free radicals to protect skin structure from oxidative stress. Anti-inflammatory actions inhibit the NF-κB pathway, reducing IL-6 by 25% and AGEs by 10%, thereby soothing chronic inflammation and redness. The extract also boosts natural hyaluronic acid synthesis and aquaporin-3 production for superior hydration, while bioavailable silicium regenerates and strengthens the skin barrier. Furthermore, it offers photoprotection against UVA/UVB radiation by decreasing oxidative and inflammatory stress markers, and promotes proteasome activity to delay photoaging effects.
Research
Clinical Evidence
High confidence1.5%
Key findings
- 01 Observed a significant reduction in wrinkle depth in the crow's feet area after 56 days of consistent use in a clinical serum study.
- 02 Demonstrated increased skin firmness and elasticity, improved facial contour, and a firmer skin texture in a clinical serum study.
- 03 Inhibited inflammatory reactions, resulting in a 25% reduction in IL-6 and a 10% reduction in Advanced Glycation End Products (AGE) in a clinical serum study.
- 04 Stimulated natural hyaluronic acid synthesis, leading to enhanced moisture retention and visibly plumper skin after 56 days of use in a clinical serum study.
- 05 Showed a significant increase in dermis density after 14 days, contributing to firmer and more elastic skin in a study with 28 participants using a cream.
- 06 A significant increase in the exfoliation index was noted after 14 days, with sustained effects observed at 28 days, in a clinical study with 29 participants using a cream.
- 07 In *in vitro* reconstructed human epidermis models, it significantly reduced oxidative and inflammatory stress markers (ROS, NO, IL-1α), cytotoxicity, and sunburn cells induced by UVA and UVB, demonstrating photoprotective effects.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Fucoxanthin within the Phaeodactylum tricornutum extract demonstrates photostability against UVA and UVB radiation. However, its antioxidant capacity may significantly decline during storage; encapsulation is shown to preserve antioxidant capacity for extended periods. Fucoxanthin from Isochrysis galbana exhibited only 15% degradation during 24-hour ethanol extraction.
Safety
Safety Profile
While 'Phaeodactylum Tricornutum Extract' was listed in a CIR report on 'Red Algae-Derived Ingredients,' no specific 'safe as used' status or maximum concentration for cosmetic use was found. The EFSA Panel on Biological Hazards (BIOHAZ) did not grant 'Phaeodactylum tricornutum' QPS status for food applications due to limited historical safety data and potential for toxic bioactive compounds at higher oral doses (adverse effects at 750 mg/kg bw/day). Conversely, 'Isochrysis galbana extract' received no hazard classification under OSHA HCS, and *in vitro* studies for Phaeodactylum tricornutum ethanolic extract demonstrated an 'excellent safety profile' for photoprotective effects on reconstructed human epidermis models.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This multi-functional microalgae extract demonstrates significant efficacy in addressing multiple signs of aging, enhancing hydration, and protecting the skin from environmental damage, making it a valuable asset for advanced skincare formulations.
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