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Moumoujus

ISOBUTYL-METHOXYPYRAZINE.

Optional CAS 24683-00-9 / PERFUMING

Isobutyl-Methoxypyrazine is a potent aroma chemical recognized for its distinctive green bell pepper and herbaceous scent profile. It is incorporated into cosmetic and personal care products solely as a perfuming agent, contributing to the olfactory experience rather than providing direct therapeutic skin benefits.

Summary

perfuming

Science

Mechanism of Action

Isobutyl-Methoxypyrazine functions exclusively as an aroma chemical, interacting with olfactory receptors to impart a specific scent. It possesses no known mechanism of action that confers direct therapeutic effects on the skin or body.

Research

Clinical Evidence

High confidence
Effective range 0.00005–0.79%
Optimal

0.79%

Key findings

  1. 01 Supported concentration for lip products, demonstrating no appreciable risk for skin sensitization based on Dermal Sensitization Threshold (DST).
  2. 02 Supported concentration for facial products applied with fingertips, demonstrating no appreciable risk for skin sensitization based on Dermal Sensitization Threshold (DST).
  3. 03 Supported concentration for leave-on face and body products applied with hands, demonstrating no appreciable risk for skin sensitization based on Dermal Sensitization Threshold (DST).
  4. 04 The highest supported concentration for products applied to hair with incidental hand contact, demonstrating no appreciable risk for skin sensitization based on Dermal Sensitization Threshold (DST).

Transparency

Dusting Analysis

Not commonly dusted

Isobutyl-Methoxypyrazine is a fragrance ingredient, not an active ingredient typically 'dusted' or used for therapeutic effects requiring specific efficacy thresholds.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

This ingredient is soluble in organic solvents and oils. While sparingly soluble in water (approximately 229.6 mg/L at 25 °C), it is practically considered oil-soluble for formulation purposes. Optimal stability is maintained when stored in a cool, dry environment, protected from direct sunlight and heat, with temperatures ideally remaining below 40°C.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0.79%
Sensitization risk Low

Comprehensive safety assessments by RIFM found 2-Isobutyl-3-methoxypyrazine to be non-genotoxic, with no predicted photoirritating potential. Based on Dermal Sensitization Threshold (DST) analysis, it poses no appreciable risk for skin sensitization at current usage levels. It is also not classified as Persistent, Bioaccumulative, or Toxic (PBT) according to IFRA Environmental Standards. The FDA recognizes it as a GRAS (Generally Recognized As Safe) flavoring agent, with JECFA similarly concluding no safety concern at typical intake levels.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Optional

As a fragrance ingredient, Isobutyl-Methoxypyrazine is an optional inclusion that enhances product sensory appeal, with a robust safety profile supporting its use across various cosmetic applications without appreciable skin sensitization risk.

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