Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

ISATIS TINCTORIA LEAF EXTRACT.

Valuable CAS - / SKIN CONDITIONING

Isatis Tinctoria Leaf Extract is a multi-functional botanical ingredient recognized for its potent anti-inflammatory, antioxidant, and anti-aging properties. It actively mitigates cellular senescence and reduces inflammatory responses, promoting healthier and more resilient skin. Additionally, it offers emollient and moisturizing benefits for enhanced skin conditioning.

Summary

Antioxidant Skin-conditioning Anti-inflammatory Anti-aging Emollient Moisturizing

Science

Mechanism of Action

This extract operates through several key pathways: it significantly inhibits various inflammatory mediators including cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), and interleukins (IL-1beta, IL-4, IL-5, IL-6), while also reducing mast cell degranulation and thymic stromal lymphopoietin (TSLP) levels. Its antioxidant action combats oxidative stress and modulates nitric oxide (NO) production. Crucially, it exhibits senolytic and senostatic effects by attenuating the pro-inflammatory senescence-associated secretory phenotype (SASP) and regulates the mTOR-NF-κB-SASP signaling pathway to inhibit replicative senescence in dermal fibroblasts, contributing to cellular longevity.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 45% inhibition of COX-2 enzyme
  2. 02 80% inhibition of COX-2 enzyme
  3. 03 Significant inhibition of acute oedema and inflammatory response
  4. 04 Displayed senolytic and senostatic effects, attenuating pro-inflammatory SASP
  5. 05 Inhibited replicative senescence by regulating mTOR-NF-κB-SASP signaling

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Specific compounds within Isatis tinctoria leaves, Isatans A and B, are more stable in acidic environments. They are thermolabile, degrading at temperatures around 40°C, and can spontaneously transform into indigo in alkaline conditions. Formulators should avoid high temperatures and alkaline pH to preserve these particular beneficial compounds.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

The CosIng Database positively evaluates Isatis tinctoria raw materials for cosmetic use in Europe. Traditional herbal medicine generally considers leaf preparations safe but cautions against use in individuals with weak constitutions. A notable concern is the presence of aspirin-like chemicals, which could potentially induce an allergic reaction or asthma attack in individuals with known aspirin sensitivities. No specific CIR, SCCS, or FDA safety status for the leaf extract has been established.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Isatis Tinctoria Leaf Extract is a valuable ingredient, offering comprehensive benefits for skin health, including significant anti-inflammatory, antioxidant, and anti-aging effects, alongside moisturizing properties.

Related

Similar Ingredients

Finding similar ingredients…