Science
Mechanism of Action
This extract delivers a potent blend of bioactive compounds, including phenolic acids, flavonoids (such as cynarin and hyperoside), and vitamins A, C, and E, alongside beta-carotene and anthocyanins. These components collectively neutralize free radicals, mitigating signs of skin maturation and environmental damage. The extract also enhances skin's moisture retention, leaving it supple, and possesses calming properties that can reduce redness and irritation. Its vitamin C content contributes to a brighter complexion, diminishing the appearance of hyperpigmentation, while its anti-inflammatory effects, evidenced by IL-6 inhibition, help soothe the skin. Furthermore, it supports the skin's natural barrier and offers antimicrobial benefits.
Research
Clinical Evidence
Medium confidenceApproximately 0.005% - 0.05%. Concentrations as low as 0.004799% (47.99 ppm) have shown antioxidant activity in vitro. Anti-inflammatory effects, marked by significant IL-6 inhibition, were observed at 0.0075% (75 µg/mL) and 0.01% (100 µg/mL) in vitro. For antimicrobial action, concentrations of 0.25% to 0.5% (2.5-5 mg/mL) demonstrated notable activity. However, human patch tests indicated irritation at 0.1% (1000 ppm) and 0.5% (5000 ppm) for 'old leaf' extracts, while 0.05% (500 ppm) did not cause irritation. Safe usage concentrations for keratinocytes were established at 0.011% (111 µg/mL).
Key findings
- 01 Orange Flesh Sweet Potato extract significantly inhibited IL-6 production by 31% and 73% respectively, in a concentration-dependent manner, demonstrating anti-inflammatory potential.
- 02 A purple sweet potato leaf extract (Antin-3 variety) exhibited antioxidant activity (IC50 value) in vitro.
- 03 Sweet potato leaves extract demonstrated notable antimicrobial activity against various bacterial strains.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The active polyphenolic compounds in the extract are susceptible to degradation when exposed to environmental factors such as air and pH variations. Nano-capsulation is a suggested strategy to protect these sensitive metabolites, thereby enhancing stability, antioxidant efficacy, and skin penetration.
Safety
Safety Profile
This ingredient has not been formally reviewed by CIR, SCCS, or FDA for a 'safe as used' or 'safe with restrictions' status. While in vitro studies indicate safety for keratinocytes up to 0.011%, human patch tests of ethanolic 'old leaf' extracts demonstrated irritation in two out of seven subjects at 0.1% and 0.5%. Extracts derived from 'young leaves' were noted to have lower irritation potential. Concentrations of 0.05% (500 ppm) from 'old leaves' did not cause irritation in the reported study.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Ipomoea Batatas Leaf/Stem Extract offers valuable antioxidant, anti-inflammatory, and hydrating benefits for various skin types, but formulators must carefully consider the extract type and concentration to mitigate potential irritation.
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References
Sources