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Moumoujus

INULA BRITANNICA FLOWER/LEAF/STEM EXTRACT.

Valuable / SKIN CONDITIONING

Inula Britannica Flower/Leaf/Stem Extract is a botanical active renowned for its multifaceted benefits, primarily functioning as a potent antioxidant and anti-inflammatory agent. It also demonstrates cellular protective and antimelanogenic properties, contributing to a more even-toned and resilient complexion. Its efficacy spans defense against oxidative stress, soothing skin, and inhibiting melanin overproduction.

Summary

Skin Conditioning Antioxidant Anti-aging Antibacterial Skin whitening/Antimelanogenic Anti-inflammatory

Science

Mechanism of Action

This extract operates through several key mechanisms: it scavenges reactive oxygen species (ROS) to protect cellular membranes from oxidative damage, thereby conferring antioxidant effects. It inhibits tyrosinase, a crucial enzyme in melanin synthesis, to mitigate hyperpigmentation. Furthermore, its active compound, 1-O-acetylbritannilactone, demonstrates significant anti-inflammatory actions by inhibiting human neutrophil elastase (HNE), suppressing the production of inflammatory mediators such as nitric oxide (NO) and prostaglandin E2 (PGE2), and downregulating the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2. The extract also exhibits antibacterial activity.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

0.05%

Key findings

  1. 01 Suppressed photohemolysis in human erythrocytes in a concentration-dependent manner, indicating cellular protective and antioxidant effects.
  2. 02 Its isolated compound, 1-O-acetylbritannilactone, significantly inhibited human neutrophil elastase (HNE) with an IC50 of 3.2 ± 0.3 µM, demonstrating potent anti-inflammatory effects.
  3. 03 At 500 µg/ml in cell culture, the extract inhibited tyrosinase activity by 29.33% to 41.74% (when fermented), suggesting antimelanogenic/skin-whitening effects with maintained high cell viability (100.26% for fermented extract, 92.15% for non-fermented).

Transparency

Dusting Analysis

Not commonly dusted

Insufficient data available to determine dusting analysis for this ingredient.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has not formally reviewed this ingredient for cosmetic safety. However, independent assessments, such as EWG Skin Deep®, rate Inula Britannica Flower Extract with 'LOW' concerns for Cancer, Allergies & Immunotoxicity, and Developmental and Reproductive Toxicity. It's important to note that the plant's addition to the U.S. Federal Noxious Weed List in 2010 relates to agricultural and environmental concerns, not direct safety for topical cosmetic application of the extract.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Inula Britannica Flower/Leaf/Stem Extract is a valuable ingredient, offering robust antioxidant, anti-inflammatory, and antimelanogenic benefits with low irritation risk and broad skin type compatibility, making it suitable for a wide range of precision skincare formulations.

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