Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

INOSITOL HEXA-PCA.

Valuable / HUMECTANT, SKIN CONDITIONING

Inositol Hexa-PCA is a precision active that synergistically combines the potent antioxidant and cellular protective benefits of Inositol Hexaphosphate with the advanced hydrating properties of Pyrrolidone Carboxylic Acid (PCA). This compound is engineered to enhance skin resilience against environmental stressors while deeply moisturizing and supporting overall skin health.

Summary

Antioxidant Humectant Photoprotective (adjunct) Anti-Acne DNA Repair

Science

Mechanism of Action

The Inositol Hexaphosphate (IP6) component functions as a robust antioxidant, actively neutralizing reactive oxygen species to prevent oxidative damage and support DNA repair mechanisms. It has demonstrated the ability to protect skin cells from UVB-induced apoptosis, thereby increasing cell viability and survival. Furthermore, inositol derivatives can influence hormonal pathways, potentially decreasing total testosterone, which is beneficial for managing hyperandrogenism-related skin concerns like acne. The Pyrrolidone Carboxylic Acid (PCA) component is a vital Natural Moisturizing Factor (NMF), enhancing the skin's capacity to attract and retain water, ensuring optimal hydration and barrier function.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

4%

Key findings

  1. 01 Topical application of a 4% Inositol Hexaphosphate (InsP6) rich gel has been shown to be absorbed through human skin, with detectable levels excreted in urine, indicating bioavailability.
  2. 02 In laboratory studies, Inositol Hexaphosphate (IP6) at a concentration of 0.5 mM effectively protected human keratinocytes (HaCaT cells) from damage induced by UVB radiation, enhancing cell viability and survival.
  3. 03 A combination of myo- and D-chiro inositol in a 40:1 ratio has demonstrated potential in ameliorating acne and excessive facial hair, particularly in conditions related to Polycystic Ovarian Syndrome (PCOS), by improving insulin resistance and decreasing total testosterone.
  4. 04 Inositol is commonly incorporated into face and neck cosmetic formulations at concentrations reaching up to 4%.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 7
0 7 14

Stability

Both Inositol (myo-inositol) and Inositol Hexaphosphate (IP6) exhibit inherent stability, with IP6 notably enhancing the stability of certain enzymes. The optimal pH range for Inositol is between 5 and 7. The combined Inositol Hexa-PCA is expected to maintain good water solubility and stability within a neutral to slightly acidic pH environment.

Conflicts

  • strong oxidizing agents

Safety

Safety Profile

CIR Status
Safe as used
Max tested
4%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has affirmed the safety of Inositol, including its phosphorylated forms, in cosmetic applications at current use concentrations. While specific safety assessments for 'Inositol Hexa-PCA' as a combined ingredient are not available, its individual components (Inositol, phosphorylated inositols, PCA) are well-established as safe, with Inositol generally recognized as safe (GRAS) by the FDA for food and dietary supplement uses. The maximum reported concentration for Inositol in face and neck preparations is up to 4%.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Inositol Hexa-PCA is a valuable, multi-functional ingredient that delivers significant antioxidant protection, supports DNA integrity, offers adjunctive photoprotection, aids in managing acne-prone skin, and provides essential hydration across all skin types.

Related

Similar Ingredients

Finding similar ingredients…