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Moumoujus

INOSINE.

Optional CAS 58-63-9 / SKIN CONDITIONING, SKIN PROTECTING

Inosine is a purine nucleoside and a vital metabolite, recognized for its roles in maintaining and protecting skin health. It is believed to modulate oxidative stress and inflammatory responses, demonstrating potential immunomodulatory and neuroprotective benefits within the skin.

Summary

skin conditioning skin protecting immunomodulatory neuroprotective antioxidant anti-inflammatory

Science

Mechanism of Action

As a purine nucleoside, Inosine is integral to purine metabolism and acts as a bioactive molecule that influences RNA editing, metabolic enzyme activity, and cellular signaling pathways. Formed from adenosine and inosine monophosphate breakdown, it exhibits immunomodulatory and neuroprotective properties. Inosine's mechanism involves modulating oxidative stress and inflammatory responses, with its effect (activation or suppression) being context-dependent on specific stimuli.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

No data is available regarding dusting or specific concentration thresholds for potential negative effects in cosmetic formulations.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Inosine presents as a white crystalline powder with water solubility ranging from approximately 10 to 21 mg/mL at 20°C. Precise optimal pH for cosmetic formulation stability is not documented, though many general cosmetic formulations target a pH between 4.5 and 6.5. For aqueous stock solutions, storage should not exceed one day, and solvent-based solutions can be stored for up to one month, strictly avoiding repeated freeze-thaw cycles.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Inosine has not undergone a specific Cosmetic Ingredient Review (CIR) safety assessment, nor has a SCCS opinion been issued for its use in cosmetics. While the FDA does not mandate pre-market approval for cosmetic ingredients, they must be safe for consumer use under intended conditions. Inosine is broadly classified as 'Over-the-counter (OTC)' for general use and also noted for antiviral properties in medical classifications. Information regarding specific sensitization risk or pregnancy safety in topical applications is not available.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Optional

Inosine offers established benefits as a skin conditioning and protecting agent with potential immunomodulatory effects, though further specific clinical efficacy data and comprehensive safety assessments for cosmetic applications are needed for a more definitive rating.

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