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INDIGOFERA TINCTORIA LEAF POWDER.

Valuable CAS 84775-63-3 / SKIN CONDITIONING, SKIN CONDITIONING - MISCELLANEOUS

A botanical ingredient sourced from the Indigofera Tinctoria plant, this powder is valued for its multi-faceted benefits, including significant anti-inflammatory and soothing properties. It actively supports skin barrier health and promotes balanced cell proliferation, making it particularly beneficial for reactive and compromised skin types.

Summary

Anti-inflammatory Antioxidant Skin barrier support Soothing Antihistamine Antibacterial Antifungal Cell proliferation regulator Moisturizing (as extract) Anti-aging (as extract)

Science

Mechanism of Action

INDIGOFERA TINCTORIA LEAF POWDER operates via active molecules such as Tryptanthrin and Indirubin. Tryptanthrin delivers antibacterial and antifungal effects while reducing redness and swelling by modulating inflammatory signals. Indirubin encourages proper skin cell growth, preventing the accumulation of scaly buildup, which is crucial for conditions like psoriasis. The ingredient also acts as an antihistamine, lowering skin reactivity. It fortifies the skin barrier by promoting filaggrin production and offers antioxidant defense against free radicals. Furthermore, active constituents within Indigo naturalis exhibit anti-proliferative, anti-inflammatory, and anti-angiogenic effects by regulating cellular pathways including TAK1, JAK3/STAT3, Wnt/β-catenin, Akt/PKB, FAK, and AP-1/c-Jun.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A topical ointment containing indigo demonstrated significant efficacy, clearing or nearly clearing plaques in 31 out of 42 psoriasis patients over a 12-week period.
  2. 02 Preclinical in vivo studies showed that Indirubin, a key active component of Indigo naturalis, ameliorated psoriasis-like symptoms, indicated by improvements in PASI score, reduced epidermal thickness, and modulated interleukin expression.
  3. 03 When formulated as an Indigofera Tinctoria Leaf Extract, concentrations of 2-5% have been recommended for their moisturizing and anti-aging effects.

Transparency

Dusting Analysis

Not commonly dusted

This ingredient contains well-documented active molecules with demonstrated clinical and preclinical efficacy, suggesting its inclusion is typically for targeted functional benefits rather than for cosmetic 'dusting'.

The Formula

Formulation

Solubility
Water
Optimal pH 7 – 9
0 7 14

Stability

The ingredient is stable at room temperature when stored in a dark environment. While raw indigo powder may temporarily stain the skin, refined extracts are commonly formulated to be 'stain-free' for cosmetic applications.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
25%
Sensitization risk Moderate

The Scientific Committee on Consumer Safety (SCCS) considers Indigofera tinctoria safe for use in non-oxidative hair colouring products at on-head concentrations up to 25%. However, a weak skin sensitisation potential cannot be excluded. While pure cosmetic-grade indigo leaf powder is generally considered non-toxic and safe for topical use, a patch test is recommended to rule out individual plant allergies. Toxicity studies in rabbits found it non-irritating to skin but caused mild eye irritation. No specific FDA status for skincare applications has been identified.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

INDIGOFERA TINCTORIA LEAF POWDER is a valuable botanical ingredient, offering robust anti-inflammatory, barrier-strengthening, and cell-regulating properties, making it highly beneficial for sensitive, dry, and compromised skin, particularly in the management of conditions like psoriasis.

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