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INDIGOFERA TINCTORIA LEAF EXTRACT.

Valuable CAS 84775-63-3 / SKIN CONDITIONING

Indigofera Tinctoria Leaf Extract is a multi-functional botanical ingredient recognized for its extensive benefits across various skin types. It precisely targets inflammation, strengthens the skin barrier, and offers robust antioxidant protection, contributing to a calmer, more resilient complexion. This extract is well-regarded for its low irritancy and comedogenicity profile.

Summary

antioxidant skin-soothing anti-inflammatory antimicrobial skin barrier strengthening moisturizing anti-aging wound healing support antihistamine

Science

Mechanism of Action

This extract operates through key active molecules: Tryptanthrin and Indirubin. Tryptanthrin delivers antimicrobial action, helping to mitigate bacterial and fungal issues, while effectively dampening inflammatory signals that lead to redness and swelling. Indirubin is crucial for optimizing skin barrier function by promoting healthy skin cell growth, thereby preventing scaly build-up and enhancing overall skin integrity. The extract's potent antioxidant profile, attributed to its ability to scavenge free radicals, provides anti-aging benefits without inducing irritation. Furthermore, its rich bioflavonoid content confers significant anti-inflammatory and antihistamine properties, which soothe chronic redness, reduce skin reactivity, and fortify the skin barrier against environmental stressors and transepidermal water loss (TEWL).

Research

Clinical Evidence

Medium confidence
Effective range 2–5%
Optimal

2-5%

Key findings

  1. 01 Topical application of 5% indigo extract demonstrated significant enhancement of wound healing in rat models, reducing dermal inflammation, elevating antioxidant enzyme activities, and modulating matrix metalloproteases and TGF-β1 levels. Skincare formulations typically recommend concentrations between 2% and 5% for its comprehensive moisturizing, antioxidant, anti-inflammatory, and barrier-strengthening effects.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH 3.9 – 7.2
0 7 14

Stability

The extract's stability, particularly its indigo dye component, decreases with temperature and pH. While the raw liquid extract exhibits a reported pH range of 3.9-7.2, the vibrant blue color of the indigo dye specifically requires a pH range of 8-14 for its maintenance and stability. The dye is also susceptible to degradation at moderate temperatures, such as 40°C, and is sensitive to light.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While the SCCNFP concluded Indigofera tinctoria powder to be non-sensitizing in guinea pig tests in 2004, human dermal sensitization studies were deemed unsuitable due to study design limitations. In vitro studies have indicated some types of the extract may be mutagenic, and partial cytotoxicity was observed at 500 µg/ml. Generally considered to have a good safety profile and acceptable in many countries under cosmetic regulations, individuals with particularly sensitive skin are advised to perform a patch test due to the potential for allergies or irritation.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Indigofera Tinctoria Leaf Extract is a valuable, multi-faceted botanical, offering significant anti-inflammatory, antioxidant, and barrier-supporting benefits suitable for a wide array of skin concerns.

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