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Moumoujus

INDIGOFERA SUFFRUTICOSA LEAF/STEM EXTRACT.

Valuable / SKIN CONDITIONING

Indigofera Suffruticosa Leaf/Stem Extract is a botanical active known for its comprehensive skincare benefits, including powerful antioxidant, anti-inflammatory, and skin barrier strengthening capabilities. It also provides significant moisturizing effects and demonstrates antimicrobial and antifungal properties.

Summary

Skin conditioning Antioxidant Anti-inflammatory Moisturizing Skin barrier support Antimicrobial Antifungal Anti-aging

Science

Mechanism of Action

This extract actively protects the skin from free radical damage, a key factor in inflammation and premature aging, through its antioxidant properties. It functions as an anti-inflammatory agent by calming irritation, reducing redness, and diminishing pro-inflammatory mediator expressions, specifically by lessening LPS-induced NF-kB activation and inducing HO-1 expression in macrophages. Additionally, it contributes to skin moisturization, reinforces the skin barrier, and exhibits direct antimicrobial action against bacteria like Staphylococcus aureus, along with antifungal activity against dermatophytes such as Trichophyton rubrum and Microsporum canis.

Research

Clinical Evidence

Medium confidence
Effective range 0.078–5%
Optimal

3.5%

Key findings

  1. 01 Recommended for moisturizing, antioxidant, anti-aging, skin barrier strengthening, and anti-inflammatory benefits (based on studies of Indigofera Tinctoria Leaf Extract, a closely related species).
  2. 02 An acetone extract of Indigofera suffruticosa leaves demonstrated minimal inhibitory concentration (MIC) against Staphylococcus aureus.
  3. 03 An acetone extract of Indigofera suffruticosa leaves achieved minimal bactericidal concentration (MBC) against Staphylococcus aureus.
  4. 04 An aqueous extract of Indigofera suffruticosa leaves showed strong inhibitory activity against Staphylococcus aureus.
  5. 05 An aqueous extract of Indigofera suffruticosa leaves exhibited strong inhibitory activity against dermatophyte strains, including Trichophyton rubrum and Microsporum canis.

Transparency

Dusting Analysis

Not commonly dusted

There is no indication that this ingredient is commonly used at concentrations below its known efficacy thresholds. Clinical studies demonstrate specific antimicrobial activity at concentrations as low as 0.078% and general skin benefits are recommended within a 2-5% range.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The stability of organic extracts of Indigofera suffruticosa leaves is influenced by temperature and pH, suggesting these are critical formulation factors. The ingredient is reported to be well-soluble in water.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

INDIGOFERA SUFFRUTICOSA LEAF/STEM EXTRACT has not undergone specific review by CIR, SCCS, or FDA. Toxicity studies in mice using high doses of aqueous extracts (up to 2400 g/kg) indicated a low order of toxicity with no deaths, though some minor signs of toxicity were observed. While Indigofera Tinctoria, a closely related species, is generally considered to have a good safety profile, patch testing is recommended for sensitive individuals due to the potential for allergies or irritation. Given that some Indigofera species may contain toxic natural products, meticulous sourcing and preparation are essential.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Indigofera Suffruticosa Leaf/Stem Extract is a valuable ingredient, delivering diverse benefits from antioxidant protection and anti-inflammatory action to potent antimicrobial and moisturizing properties, making it highly beneficial for supporting overall skin health.

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