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ILEX GUAYUSA LEAF EXTRACT.

Valuable CAS - / SKIN PROTECTING

Derived from the Guayusa leaf, this extract offers significant antioxidant protection, effectively combating oxidative stress. It is recognized for its ability to enhance skin elasticity and firmness, while also providing soothing anti-inflammatory benefits.

Summary

Antioxidant Skin Protecting Anti-inflammatory Firming Elasticity Enhancing

Science

Mechanism of Action

Ilex Guayusa Leaf Extract functions through a rich array of phenolic compounds, including potent polyphenols, flavonoids like quercetin and kaempferol, and chlorogenic acids. These components neutralize free radicals, mitigating oxidative stress linked to premature skin aging. Its anti-inflammatory action stems from caffeoylquinic acids, which reduce nitric oxide (NO) production, and additional contributions from pentacyclic triterpenoids such as ursolic acid. Furthermore, the presence of caffeine can promote peripheral blood flow, contributing to its overall skin benefits, including improved elasticity and firmness.

Research

Clinical Evidence

Medium confidence
Effective range 5–5%
Optimal

5%

Transparency

Dusting Analysis

Not commonly dusted

No data is available within the research provided to assess the dusting potential or common dusting practices for Ilex Guayusa Leaf Extract.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

This extract has been successfully integrated into both hydrophilic (gel) and lipophilic (cream) cosmetic systems, indicating versatile formulation compatibility. While no specific optimal pH range is defined, variations in pH are noted to influence its antioxidant efficacy. Preheating the raw material during extract manufacturing can aid in preserving its beneficial polyphenols and carotenoids by inactivating enzymes.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
5%
Sensitization risk Low

The FDA has granted aqueous Ilex guayusa leaf extract (aqueous-IGLE) 'Generally Recognized As Safe' (GRAS) status for specific food applications (up to 4% in bars, 1% in beverages). In topical applications, a 5% hydroglyceric extract was used in a clinical study. In vitro toxicity tests showed low to median toxicity, and an in vivo rat study classified it as a low toxicity plant (LD50 >5000 mg/kg). Mutagenicity (Ames test) and clastogenicity tests in human cells were negative, indicating a low risk for genetic harm.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Ilex Guayusa Leaf Extract is a valuable ingredient, praised by INCIDecoder as 'best', offering significant antioxidant, anti-inflammatory, and skin-firming benefits with broad skin compatibility.

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