Science
Mechanism of Action
This extract operates through a multifaceted mechanism, primarily leveraging its rich content of phenolic compounds and polysaccharides. It effectively neutralizes free radicals via direct scavenging, enhancing reducing power, and chelating ferrous ions, while also inhibiting lipid peroxidation to prevent oxidative damage. Its anti-inflammatory action is mediated by modulating LTB4-driven chemotaxis and/or IL-1β-induced adhesion of polymorphonuclear leukocytes.
Research
Clinical Evidence
Medium confidence0.1%
Key findings
- 01 In vitro studies utilizing an ethanoic extract demonstrated robust antioxidant activity at a 0.1% (1000 µg/mL) concentration, exhibiting 85% DPPH radical-scavenging, 65% hydroxyl radical scavenging, and 70% ABTS radical-scavenging activity. Furthermore, the mycelial extract displayed superior anti-inflammatory effects compared to the fruiting body extract in carrageenan- and formalin-induced paw edema models.
Transparency
Dusting Analysis
No specific data available regarding common dusting practices or thresholds for this ingredient in cosmetic formulations.
The Formula
Formulation
Stability
While the Hypsizygus ulmarius mycelium thrives optimally in a pH range of 6-8, specific optimal pH conditions for the stability of its cosmetic extract are not extensively detailed. Extracts are typically prepared using aqueous ethanol.
Safety
Safety Profile
Formal safety reviews by CIR, SCCS, or FDA are currently unavailable. However, its inclusion on SkinSAFE with an 'Irritant Free' filter option suggests a generally well-tolerated profile for topical cosmetic use, with low potential for irritation.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Hypsizygus ulmarius mycelium extract is a valuable ingredient, demonstrating significant antioxidant and anti-inflammatory capabilities crucial for protective and soothing skincare formulations.
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References
Sources