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HYPERICUM PERFORATUM CALLUS CULTURE EXTRACT.

Valuable CAS 84082-80-4 / ANTIOXIDANT, HAIR CONDITIONING, HUMECTANT, SKIN PROTECTING

Hypericum Perforatum Callus Culture Extract is a plant-derived ingredient rich in phenolic acids, flavonoids, and naphthodianthrones, offering multi-functional benefits. It acts as a potent antioxidant, humectant, and skin protector, with promising preclinical evidence for skin regeneration and wound healing.

Antioxidant Humectant Skin protecting Wound healing support Antibacterial

Science

This extract leverages a rich profile of phytochemicals, including phenolic acids, flavonoids (e.g., quercetin), and naphthodianthrones (e.g., hypericin, hyperforin). As an antioxidant, it actively neutralizes reactive oxygen species, protecting skin from environmental aggressors and preventing ingredient degradation. It forms a protective barrier on the skin, shielding it from external influences, and functions as a humectant by attracting and retaining moisture. In the context of wound healing, it supports angiogenesis, facilitates re-epithelialization, promotes collagen deposition, and may mitigate fibrosis. Certain components, like hypericin, also possess photosensitizing and anti-proliferative properties.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

No data available in the provided research to suggest 'dusting' concerns for this ingredient.


The Formula

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Active compounds such as hyperforin and hypericin are known to be sensitive to degradation when exposed to sunlight, heat, and air. Specifically, hypericin may exhibit precipitation under acidic pH conditions.

Conflicts

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Safety

CIR Status
Safe as used
Sensitization risk Unknown

The CIR Expert Panel concluded in March 2013 that Hypericum perforatum-derived ingredients, including its callus culture extract, are 'safe as used' in cosmetic applications. However, no specific maximum concentration for cosmetic use was provided for this extract in the available CIR documentation. The report included standard cautionary language regarding potential additive effects from constituent chemicals or impurities, particularly when multiple botanical ingredients are present. No specific SCCS opinion or FDA cosmetic status was identified for this ingredient.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Valuable

This extract is a valuable multi-functional ingredient offering significant antioxidant, hydrating, and protective properties, supported by a 'safe as used' CIR status, though further human clinical data for cosmetic efficacy would enhance its profile.


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