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HYDROXYPROPYLTRIMONIUM HYALURONATE.

Valuable CAS - / FILM FORMING

Hydroxypropyltrimonium Hyaluronate is an advanced, cationic derivative of hyaluronic acid engineered for superior skin adhesion. This modified form provides deep, long-lasting hydration by forming a protective film and strengthening the skin barrier, significantly outperforming conventional hyaluronic acid in substantivity.

Humectant Moisturizing Anti-aging Film-forming Antioxidant

Science

This ingredient possesses a positive charge, facilitating an electrostatic attraction with the naturally negatively charged surface of the skin. This enhanced affinity significantly improves its adsorption, allowing it to adhere longer and resist being easily removed. It functions as a powerful humectant, drawing and retaining water to deliver deep and sustained hydration. By forming a protective, breathable film on the skin, it strengthens the skin barrier and helps to alleviate irritation. Furthermore, it is observed to stimulate collagen production, enhance skin elasticity, and visibly diminish the appearance of wrinkles, while also contributing to pH regulation and acting as an antioxidant.


Research

High confidence
Effective range 0.1–2%
Optimal

N/A

Key findings

  1. 01 Clinical studies demonstrate that at concentrations ranging from 0.1% to 2%, Hydroxypropyltrimonium Hyaluronate significantly increases moisture retention and improves skin hydration over a 24-hour period. This derivative is clinically proven to boost skin's hydration both instantly and long-term, and to strengthen the skin barrier, exhibiting greater substantivity than conventional hyaluronic acid.

Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH 5 – 7.5
0 7 14

Stability

This is a stable form of hyaluronic acid. Its cationic modification resolves common solubility and compatibility issues, making it highly suitable for incorporation into surfactant systems.


Safety

CIR Status
Safe as used
Sensitization risk Low

Generally regarded as safe for topical application. The Cosmetic Ingredient Review (CIR) Expert Panel has deemed hyaluronic acid derivatives, including this one, safe for use. Studies indicate a low incidence of allergic reactions or skin irritations, and it holds a low hazard rating by EWG.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

Hydroxypropyltrimonium Hyaluronate is a valuable, enhanced hyaluronic acid derivative offering superior, long-lasting hydration and barrier support across all skin types with a high safety profile.


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