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Ingredient directory

Hydroxypropyl Bisstearamide Mea

Hydroxypropyl Bisstearamide MEA is a sophisticated biomimetic ceramide, engineered to closely mimic the natural ceramides essential for healthy skin. It actively works to restore and fortify the skin's barrier function, significantly enhancing moisture retention and promoting a smoother, more resilient complexion.

Directory entry · Individual source review pending

This profile is awaiting an individual source review. Treat its ratings, dose estimates and compatibility labels as provisional; they are not medical advice or proof of a finished product’s effects.

Skin-identical ingredient Emollient Conditioning agent

Science

Mechanism of Action

This ingredient functions as a skin-identical lipid, directly replicating the critical role of native ceramides within the skin's intercellular lipid matrix. Ceramides are vital for maintaining the structural integrity of the skin barrier, effectively reducing transepidermal water loss (TEWL), and offering protection against environmental stressors and irritants. By acting as both a conditioning agent and an emollient, Hydroxypropyl Bisstearamide MEA helps to lock in moisture, prevent its loss, and strengthen the skin's surface, leading to noticeably softer, smoother, and healthier-looking skin. Additionally, it imparts a desirable creamy texture to formulations.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Claimed to be similarly effective as Ceramide 3 in moisturizing the skin and aiding in the restoration and strengthening of the skin barrier.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Alkaline microenvironmental pH can contribute to faster degradation rates when formulated with reducing sugars such as lactose.

Conflicts

  • Must not be used in cosmetic products where N-nitroso compounds may be formed, due to the potential for free ethanolamine release.
  • Avoid formulating with reducing sugars in alkaline microenvironments to prevent accelerated degradation.

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
17%
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) Expert Panel has assessed this ingredient, along with related ethanolamides, as safe for use under specific conditions. In leave-on products, it is safe at concentrations up to 17%, provided that the release of free ethanolamine is limited to 5%. It is critical to ensure this ingredient is not used in cosmetic products where N-nitroso compounds could be generated.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

As a biomimetic ceramide, Hydroxypropyl Bisstearamide MEA is a valuable ingredient for fortifying the skin barrier, improving moisture retention, and promoting overall skin health, particularly beneficial for dry and sensitive skin, provided stringent formulation guidelines are adhered to.

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