Science
Mechanism of Action
Operating as a highly effective cationic compound, Hydroxypropyl Bis-Hydroxyethyldimonium Chloride exhibits outstanding water-binding capabilities due to its high charge density and hygroscopic nature. It functions as an osmoregulator, actively drawing moisture from the environment and depositing a hydrated humectant film matrix onto the skin via strong ionic and hydrogen bonding, thereby preventing transepidermal water loss and sustaining a protective humidity gradient.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Clinical trials evaluating humectant efficacy at 10% and 30% Relative Humidity revealed its superior water-binding performance when compared to conventional humectants such as Glycerin, Sodium PCA, Sodium Lactate, and Urea. Its incorporation into lotion formulations was shown to extend moisturizing benefits for a duration of 8 to 24 hours.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Stable across a broad range of temperatures and pH, but should not be exposed to heat exceeding 80°C.
Safety
Safety Profile
While not recognized as GRAS (Generally Recognized As Safe) for ingestion, this ingredient is generally assessed for topical cosmetic use. Acute skin irritation tests with a 5.0% solid solution on 52 test subjects showed no potential for dermal irritation. Eye irritation tests at 2% and 5% solid solutions indicated a 'non-irritating' classification and practically no ocular irritation potential, respectively. EWG rates common concerns for this ingredient as LOW for Cancer and Allergies.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This ingredient is a valuable, high-efficacy humectant demonstrated to provide superior and long-lasting moisturization for various skin types.
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