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HYDROXYMETHOXYPHENYL DECANONE.

Valuable CAS 27113-22-0 / SKIN CONDITIONING

Hydroxymethoxyphenyl Decanone is a multifunctional active ingredient known for its capacity to significantly enhance the skin's intrinsic hyaluronic acid production. It also provides robust antioxidant defense and anti-irritant benefits, promoting overall skin health and resilience.

Skin Conditioning Antioxidant Anti-irritant Hyaluronic Acid Booster

Science

This compound acts primarily as a powerful hyaluronic acid (HA) booster, stimulating the natural synthesis of HA within both the dermal and epidermal layers of the skin. Concurrently, it functions as a potent antioxidant, neutralizing free radicals and mitigating oxidative stress from environmental aggressors, which contributes to reducing the visibility of fine lines, wrinkles, and dark spots. Furthermore, Hydroxymethoxyphenyl Decanone exhibits anti-irritant and soothing properties by inhibiting inflammatory mediators, thus reinforcing the skin's barrier function and fostering a more even skin tone.


Research

Medium confidence
Effective range 0.05–0.2%
Optimal

0.05%

Key findings

  1. 01 An ex vivo human skin model demonstrated that this ingredient stimulated dermal hyaluronic acid levels by 259% and epidermal hyaluronic acid levels by 198% compared to a placebo.
  2. 02 Recommended for use in ingredient blends, specifically with bisabolol, at concentrations between 0.05% and 0.2% to optimize hyaluronic acid production and skin-soothing effects.

Transparency

Not commonly dusted

The Formula

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Hydroxymethoxyphenyl Decanone demonstrates excellent stability within cosmetic formulations and readily blends with other active components. It also protects formulations, oils, and sensitive materials from oxidative degradation, thereby preserving their color, odor, and overall activity.

Synergies

  • Bisabolol (enhances hyaluronic acid production and soothing properties)

Safety

CIR Status
Not reviewed
Max tested
2%
Sensitization risk Low

Generally regarded as safe for use in cosmetics and meets regulatory standards in the European Union and the US FDA. While some individuals may experience mild skin irritation or allergic reactions, independent evaluations by EWG Skin Deep indicate low concerns for cancer, allergies, immunotoxicity, developmental and reproductive toxicity, and usage restrictions. Manufacturers typically recommend usage up to 2%.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Valuable

Hydroxymethoxyphenyl Decanone is a valuable ingredient, effectively boosting hyaluronic acid production and offering significant antioxidant and anti-irritant benefits across all skin types.


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