Science
Mechanism of Action
This ingredient functions as a TRPV1 antagonist, a targeted neurocosmetic action that directly intervenes with the TRPV1 nociceptive receptor, which is critical for transmitting itch (pruritogenic) and pain (analgesic) signals in sensory neurons. By inhibiting the overactivation of these neurons, it effectively reduces discomfort at its source. Recognized as a natural analog of capsaicin, it demonstrates superior anti-inflammatory potency, helping to alleviate skin redness and irritation. Further, it supports skin health by reinforcing the epidermal barrier and providing antioxidant protection against environmental stressors.
Research
Clinical Evidence
Medium confidence0.025%
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
While no specific safety assessments from CIR, SCCS, or FDA were found, Taiwan's Cosmetic Hygiene and Safety Act indicates specific restrictions regarding maximum allowable limits, required label warnings, and designated uses for this ingredient in certain product categories (e.g., antiperspirant & deodorant, hair dye).
Your Skin
Skin Compatibility
Our Assessment
Verdict
This ingredient offers valuable, targeted relief for sensitive and reactive skin by effectively reducing itch and discomfort at a neurological level, while simultaneously bolstering skin barrier function and providing antioxidant protection.
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References
Sources