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Ingredient directory

Hydroxyethyl Palmityl Oxyhydroxypropyl Palmitamide

This advanced ceramide-mimetic lipid is engineered to integrate into the skin's natural barrier, reinforcing its structural integrity and significantly reducing transepidermal water loss. It enhances overall skin hydration and fortifies its defenses against environmental aggressors, making it particularly beneficial for compromised skin.

Directory entry · Individual source review pending

This profile is awaiting an individual source review. Treat its ratings, dose estimates and compatibility labels as provisional; they are not medical advice or proof of a finished product’s effects.

skin conditioning emollient humectant

Science

Mechanism of Action

Hydroxyethyl Palmityl Oxyhydroxypropyl Palmitamide, also known as Cetyl-PG Hydroxyethyl Palmitamide, functions by mimicking the structure and physiological role of natural ceramides within the skin's lipid matrix. It effectively fills microscopic gaps between corneocytes, thereby restoring the integrity of the stratum corneum. This action prevents excessive transepidermal water loss (TEWL), enhances cellular cohesion, and strengthens the skin's intrinsic barrier. Its ability to form organized lamellar structures, similar to natural ceramides, promotes deep hydration and mitigates sensitivity, even in skin compromised by factors such as corticosteroid use.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

The ingredient maintains stability under typical storage conditions. However, prolonged exposure to extreme heat or intense light may compromise its integrity. It exhibits excellent compatibility within formulations, seamlessly blending with a wide array of cosmetic components, including hydrating agents, various ceramides, antioxidants, and plant extracts, without disrupting their efficacy or stability.

Synergies

  • hydrating agents
  • ceramides
  • antioxidants
  • plant extracts

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

Cetyl-PG Hydroxyethyl Palmitamide is generally regarded as safe for use in cosmetic applications, demonstrating low potential for irritation and suitability for most skin types, including sensitive complexions. It is registered within the FDA Global Substance Registration System (GSRS) under UNII ISA73Z2140.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

As a potent ceramide-mimetic, this ingredient is invaluable for repairing compromised skin barriers, profoundly enhancing hydration, and improving resilience across all skin types.

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