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HYDROXYETHYL ISOBUTYL PIPERIDINE CARBOXYLATE.

Valuable CAS 119515-38-7 / ANTIMICROBIAL

Hydroxyethyl Isobutyl Piperidine Carboxylate, also known as Picaridin or Icaridin, is a synthetic compound engineered for its effective and broad-spectrum insect repellent capabilities. It delivers sustained protection against a diverse range of biting insects, alongside a favorable safety profile and low potential for skin irritation.

Summary

insect repellent antimicrobial agent

Science

Mechanism of Action

This ingredient operates by strategically disrupting the insect's olfactory system. It targets specific odorant receptor cell types and ionotropic receptors, thereby hindering the insect's ability to identify and be drawn to host cues. Additionally, it may stimulate the sensory hairs located on insect antennae, actively deterring their approach.

Research

Clinical Evidence

High confidence
Effective range 10–20%
Optimal

20%

Key findings

  1. 01 Demonstrated effectiveness against mosquitoes and ticks for a duration of 5 to 12 hours.
  2. 02 Achieved greater than 95% protection against mosquitoes over a 5-hour period.
  3. 03 Considered safe for long-term adult use, providing 12 hours of protection against ticks, 8-14 hours against mosquitoes, and up to 8 hours against biting flies, gnats, chiggers, and sand flies.

Transparency

Dusting Analysis

Not commonly dusted

As a precision insect repellent, this ingredient's efficacy is tied to specific, studied concentrations; it is not typically 'dusted' in cosmetic formulations.

The Formula

Formulation

Solubility
Oil
Optimal pH 4 – 9
0 7 14

Stability

Picaridin exhibits robust stability against hydrolysis across a wide range of environmental pH and temperature conditions. It also shows excellent compatibility with various materials, including common plastics, synthetics, sealants, building coatings, metals, and painted surfaces.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
20%
Sensitization risk Low

Licensed by the FDA and registered by the US EPA in 2001. The World Health Organization (WHO) affirmed its effectiveness and safety for human exposure in 2001 following comprehensive toxicological assessments. Products up to 20% are considered safe for long-term use in adults. It is regarded as less irritating than DEET, not a dermal sensitizer, and generally not irritating to the skin, though it may induce slight to moderate eye irritation. While no specific SCCS opinion for cosmetic use was found, it is approved as an active substance in biocidal products by the EU.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Hydroxyethyl Isobutyl Piperidine Carboxylate is a valuable ingredient, delivering scientifically-backed, long-lasting, and broad-spectrum insect protection with a favorable safety and low skin irritation profile.

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