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HYDROXYETHOXYPHENYL BUTANONE.

Valuable CAS 569646-79-3 / PRESERVATIVE, SKIN CONDITIONING

Hydroxyethoxyphenyl Butanone is a precision skincare ingredient engineered to rapidly soothe sensitive and reactive skin. It directly targets nerve hyper-reactivity to provide immediate relief from sensations of stinging, burning, and itching, while also supporting overall skin barrier function.

Summary

Preservative Skin-Conditioning Agent

Science

Mechanism of Action

This active precisely modulates the TRPV1 thermo-receptor, a key neuro-receptor involved in pain and sensation, at the cellular communication level. By reducing excessive calcium flux within the cellular membrane, it calms overactive sensory neurons, thereby diminishing nerve hyperactivation. This action effectively increases the skin's tolerance threshold to various environmental and internal stressors. Additionally, it functions as a humectant, enhancing skin hydration.

Research

Clinical Evidence

High confidence
Effective range 0.3–0.9%
Optimal

N/A

Key findings

  1. 01 Clinical evaluations demonstrate that Hydroxyethoxyphenyl Butanone, used at concentrations between 0.3% and 0.9%, significantly reduces symptoms associated with sensitive skin, including burning and stinging. It effectively lowers capsaicin-induced discomfort below the sensory threshold immediately after application, providing instant relief.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The raw material (R0069279A) exhibits water solubility at 7.59 g/L at 20°C ± 0.5 °C. It is stable for over two months when stored at 45°C in hydroalcoholic solutions. This ingredient demonstrates resistance to oxidative, heat, acid, and basic stresses, though it is sensitive to photostress. The commercial blend, SymSitive 1609, is glycol soluble.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0.7%
Sensitization risk Low

Reviewed by the SCCS (Scientific Committee on Consumer Safety) in the EU, Hydroxyethoxyphenyl Butanone is considered safe as a cosmetic preservative. It is approved for use in rinse-off, oral care, and leave-on cosmetic products at a maximum concentration of 0.7%. It was formally added to Annex V of the EU Cosmetics Regulation on November 6, 2019. The SCCS also specified that its use as a skin conditioning agent must not exceed its authorized preservative concentration of 0.7%.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Hydroxyethoxyphenyl Butanone is a valuable ingredient for addressing skin sensitivity, offering rapid soothing and reducing hyper-responsiveness by precisely modulating nerve receptors, while also contributing preservative benefits within regulatory guidelines.

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