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Moumoujus

HYDROXYCITRONELLAL DIMETHYL ACETAL.

Valuable CAS 141-92-4 / PERFUMING

Hydroxycitronellal Dimethyl Acetal is a molecularly stable fragrance compound, deriving its properties from an acetal functional group. Beyond its aromatic contribution, this ingredient provides significant and prolonged protection against mosquitoes.

Summary

Fragrance Mosquito Repellent Anti-inflammatory (potential)

Science

Mechanism of Action

The primary mechanism of Hydroxycitronellal Dimethyl Acetal involves its robust acetal structure, which enhances molecular stability and facilitates controlled release. This slow-release characteristic is crucial for extending both its olfactory presence and its duration of efficacy as a mosquito repellent. Furthermore, acetal derivatives may offer anti-inflammatory benefits and possess the capacity to bind to skin through thiol groups, leading to localized accumulation via a Schiff base intermediate.

Research

Clinical Evidence

High confidence
Effective range 0.1–5%
Optimal

5%

Key findings

  1. 01 Laboratory studies employing a human-bait methodology demonstrated that a 0.1% concentration, when applied topically, achieved 95% protection efficacy against *Aedes albopictus* mosquitoes.
  2. 02 Field trials conducted in areas with high *Aedes albopictus* density showed that a 5% concentration delivered 99% protection at the time of application. This efficacy was sustained at 94.2% after 3.5 hours and remained at 79% after 7 hours.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

The acetal structure generally confers superior stability against degradation compared to parent aldehyde compounds, notably exhibiting enhanced photostability. It demonstrates robust stability in alkaline media, making it suitable for formulations in such environments. However, related acetals are reported to be susceptible to instability in aqueous acidic conditions.

Conflicts

  • Aqueous acidic media (potential instability for related acetals)

Safety

Safety Profile

CIR Status
Safe as used
Max tested
10%
Sensitization risk Low

Hydroxycitronellal Dimethyl Acetal has been assessed as safe for use by the Cosmetic Ingredient Review (CIR) at concentrations up to 10.0%. It is also recognized as Generally Recognized As Safe (GRAS) by FEMA and listed by the FDA as a flavoring agent. Extensive safety data indicates a low risk for genotoxicity, repeated dose toxicity, and reproductive toxicity. Furthermore, it is not expected to be photoirritating or photoallergenic, and current usage levels pose no safety concerns for skin sensitization.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Hydroxycitronellal Dimethyl Acetal is a valuable ingredient, offering a stable fragrance profile and clinically proven, long-lasting efficacy as a mosquito repellent, supported by a strong safety record for diverse skin types.

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