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Moumoujus

HYDROXYBENZYL ALCOHOL.

Insufficient Data CAS 623-05-2 / SKIN CONDITIONING

Hydroxybenzyl Alcohol is a phenolic compound recognized for its antioxidant, anti-inflammatory, and potential skin-brightening capabilities. It actively targets oxidative stress and inflammatory pathways, while also showing promise in inhibiting melanin production.

Summary

Antioxidant Anti-inflammatory Skin Brightening

Science

Mechanism of Action

This ingredient operates by inhibiting the production of nitric oxide (NO) and reactive oxygen species (ROS), and by reducing levels of inducible nitric oxide synthase (iNOS), thereby acting as an antioxidant and anti-inflammatory agent. Additionally, it demonstrates an inhibitory effect on tyrosinase activity, a crucial enzyme in melanin biosynthesis, which contributes to its potential in reducing hyperpigmentation.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In laboratory cell cultures (RAW 264.7 cells), concentrations of 0.5 to 1 mM effectively inhibited LPS-induced production of nitric oxide and reactive oxygen species, concurrently decreasing iNOS levels, indicating robust antioxidant and anti-inflammatory activity.
  2. 02 In a rat model of inflammation, administrations of 1.5 to 4.5 mg per animal significantly reduced exudate volume and leukocyte infiltration, demonstrating anti-inflammatory effects.
  3. 03 Research suggests an inhibitory effect on tyrosinase activity and melanogenesis, pointing to its potential for addressing hyperpigmentation.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

As a phenolic compound, Hydroxybenzyl Alcohol exhibits greater stability under acidic conditions and is more susceptible to oxidation at neutral to alkaline pH. Its stability is also influenced by solvent, temperature, and light exposure, degrading more rapidly in solution than in its solid state. It is advisable to store this light-sensitive ingredient at low temperatures (2-8 °C) and protect it from light, ideally in amber containers. Decomposition commences above 149.1 °C.

Conflicts

  • strong oxidizers
  • acids
  • acid chlorides
  • inorganic substances

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

A specific Cosmetic Ingredient Review (CIR) for Hydroxybenzyl Alcohol is currently unavailable. However, Benzyl Alcohol, a chemically related compound, was deemed safe by CIR for cosmetic use up to 5% (with infant/child considerations) and up to 10% in hair dyes. Hydroxybenzyl Alcohol is listed by the FDA as a flavoring agent or adjuvant. No specific SCCS opinion has been issued for this compound.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While initial studies demonstrate promising antioxidant, anti-inflammatory, and tyrosinase-inhibiting mechanisms, comprehensive human topical efficacy and safety data are currently insufficient for a definitive assessment in precision skincare formulations.

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