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HYDROLYZED THEOBROMA GRANDIFLORUM FRUIT.

Valuable CAS 394236-97-6 / ASTRINGENT, SKIN PROTECTING

Derived from the Amazonian Cupuaçu fruit, HYDROLYZED THEOBROMA GRANDIFLORUM FRUIT is a water-soluble ingredient recognized for its potential to deeply hydrate, condition, and protect the skin. It supports skin regeneration by stimulating cellular processes and enhancing the skin's natural reparative capabilities.

Summary

Skin conditioning Moisturizing Astringent Skin protective Regenerative

Science

Mechanism of Action

This ingredient functions as an astringent, contributing to skin tightening and offering a protective barrier against environmental aggressors. Its hydrophilic nature, evidenced by related Cupuaçu forms, facilitates profound hydration, thereby improving skin suppleness, softness, and elasticity. Key components like phytosterols help regulate the skin's water balance and lipid activity, promoting healing. Furthermore, studies on Cupuaçu seed extract indicate its capacity to stimulate cell proliferation and migration, upregulating genes such as MKI67 for cellular proliferation, ELN for elastin, and HAS2 for hyaluronic acid synthesis, which collectively contribute to dermal regeneration. Fatty acids present may also modulate inflammatory responses and aid in wound healing processes.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In formulations utilizing nanocapsules (with >94% entrapment efficiency of Cupuaçu seed extract), significant stimulation of cell proliferation and migration was observed. A reparative gene expression profile, including MKI67, ELN, and HAS2, was verified. These formulations were non-irritating to reconstructed human epidermis and maintained physical stability for at least 120 days. Chitosan coating further enhanced active ingredient penetration into undamaged skin.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

While the plant thrives in a pH range of 5-6.5, and Cupuaçu pulp exhibits stable pH in certain food applications, a specific optimal pH range for the stability of HYDROLYZED THEOBROMA GRANDIFLORUM FRUIT in cosmetic formulations is not explicitly defined. However, formulations containing Cupuaçu seed extract within nanocapsules have demonstrated robust physical stability for a minimum of 120 days.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Although not specifically reviewed by CIR, SCCS, or FDA for 'HYDROLYZED THEOBROMA GRANDIFLORUM FRUIT', formulations incorporating Cupuaçu seed extract within nanocapsules have been clinically assessed as non-irritating to reconstructed human epidermis, suggesting a low potential for skin sensitization for related forms.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

HYDROLYZED THEOBROMA GRANDIFLORUM FRUIT offers valuable skin regenerative, moisturizing, and protective benefits, making it a promising component for advanced skincare formulations, particularly for dry and sensitive skin types.

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