Science
Mechanism of Action
Functioning primarily as a robust skin conditioning agent, Hydrolyzed Spider Web meticulously maintains and improves skin integrity. It deeply moisturizes the stratum corneum, effectively preventing dryness and flakiness, while concurrently promoting a softer, smoother, and more supple skin feel. By establishing a protective yet breathable film on the skin's surface, it optimizes moisture retention and perceptibly enhances skin texture. Furthermore, specific spider web peptides, precisely in the 10-70 KDa molecular weight range, have demonstrated the capacity to inhibit melanin synthesis and suppress the expression of pro-inflammatory cytokines induced by ultraviolet radiation.
Research
Clinical Evidence
Medium confidence1%
Key findings
- 01 A clinical evaluation revealed that a 1% concentration of specific spider web peptides (10-70 KDa) exhibited a significant inhibitory effect on melanin production and mitigated inflammatory cytokine expression following ultraviolet irradiation, suggesting potential for skin brightening and anti-inflammatory applications.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The C-terminal domain of spider silk proteins can become structurally unstable when exposed to acidic conditions, specifically at pH levels below 5.7. This is aligned with observations of natural spider silk liquid, whose pH decreases from 7 in the gland to approximately 5.5 upon extrusion.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has evaluated 'Hydrolyzed Silk,' which includes spider silk, and concluded its safety for topical application in cosmetic formulations under current usage practices and concentrations. While generally well-tolerated, rare instances of skin irritation, redness, itching, or allergic reactions have been reported, making a preliminary patch test advisable.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Hydrolyzed Spider Web is a valuable ingredient, offering broad benefits through its skin conditioning, moisturizing, and barrier-supporting actions, complemented by promising data for brightening and soothing the skin.
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References
Sources