Science
Mechanism of Action
This hydrolyzed protein derivative leverages key components like sesamin to combat oxidative stress within skin cells, a primary driver of aging and various skin disorders. It effectively reduces inflammation and swelling by inhibiting COX-2 and i-NOS protein expression through reduced NF-ĸB activation, particularly beneficial against UVB-induced damage. Furthermore, sesamin influences cellular pathways by elevating TIMP-1, suppressing MAP kinase phosphorylation, and downregulating MMP expression, offering protection against photodamage and the formation of wrinkles. As a hydrolyzed protein, it acts as a conditioning agent, while its omega-6 fatty acid content, derived from sesame oil, supports a healthier skin barrier by aiding moisturization and natural ceramide and lipid recovery.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Hydrolyzed sesame protein maintains high solubility, over 90%, across a broad pH spectrum from 2.0 to 10.0. However, its solubility is notably reduced around its isoelectric point, which occurs between pH 5.0 and 5.5. Optimal solubility is achieved in more acidic (e.g., pH 3.0) or alkaline (e.g., pH 8.0-10.0) conditions.
Safety
Safety Profile
While Hydrolyzed Sesame Seed Extract itself has not been specifically reviewed by the CIR Expert Panel, related sesame-derived ingredients (such as Sesamum Indicum (Sesame) Seed Oil) are generally deemed safe for cosmetic use. The EWG Skin Deep database assigns a low concern for cancer, allergies, immunotoxicity, and developmental/reproductive toxicity. Hydrolyzed vegetable proteins are generally recognized as safe (GRAS) by the FDA as food additives. Patch testing is recommended for individuals with sensitive skin or known nut allergies.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A versatile ingredient offering significant antioxidant, anti-inflammatory, and barrier-supporting benefits across all skin types, with a low risk of irritation.
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