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HYDROLYZED PIG PLACENTA EXTRACT.

Valuable / ANTIOXIDANT

Hydrolyzed Pig Placenta Extract is a bioactive complex rich in peptides, growth factors, and essential nutrients. It is clinically proven to significantly enhance skin hydration and elasticity, while effectively reducing the appearance of wrinkles, promoting a more resilient and youthful complexion.

moisturizer/humectant film-forming agent

Science

This ingredient employs a multi-faceted mechanism to rejuvenate the skin. It stimulates dermal fibroblasts, thereby boosting the synthesis of vital structural components such as collagen, elastic fibers, and endogenous hyaluronic acid. Additionally, it acts as an elastase inhibitor, helping to preserve the skin's natural elasticity. Its high amino acid content improves surface hydration, while larger peptide and protein molecules form a protective film, effectively minimizing transepidermal water loss (TEWL). It also upregulates Type I collagen production and accelerates the expression of key moisturizing proteins like ceramide synthase (CERS3), filaggrin (FLG), transglutaminase 1 (TGM1), and kallikrein 7 (KLK7). Furthermore, it inhibits collagen-degrading enzymes (e.g., MMP-2, MMP-9) and promotes tissue inhibitors (TIMP-1, TIMP-2), enhancing collagen integrity.


Research

High confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Water-soluble, peptide-enriched hydrolyzed and fermented placenta powder formulations have been developed and reported to exhibit good stability.


Safety

CIR Status
Not reviewed
Sensitization risk Low

EWG Skin Deep assesses 'Hydrolyzed Placental Extract' with low concerns regarding cancer, allergies & immunotoxicity, and developmental & reproductive toxicity. Products containing this ingredient are allowed within EWG VERIFIED™ criteria subject to specific usage restrictions and contamination limits. A safety evaluation of a fermented, peptide-enriched hydrolyzed swine placenta extract powder indicated an acute oral LD50 greater than 5000 mg/kg body weight in rats, with no mutagenic potential observed in standard assays. A 28-day oral toxicity study showed no adverse effects at doses up to 1000 mg/kg, establishing a No Observed Adverse Effect Level (NOAEL) greater than 1000 mg/kg body weight. Its safety has been certified by the Japanese Institute for Health Food Standards (JIHFS).


Your Skin

Yes Normal
Yes Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Valuable

Hydrolyzed Pig Placenta Extract is a valuable multi-functional ingredient demonstrating significant efficacy in enhancing skin hydration, elasticity, and reducing wrinkles, supported by a favorable safety profile.


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