Science
Mechanism of Action
This ingredient employs a multi-faceted mechanism to rejuvenate the skin. It stimulates dermal fibroblasts, thereby boosting the synthesis of vital structural components such as collagen, elastic fibers, and endogenous hyaluronic acid. Additionally, it acts as an elastase inhibitor, helping to preserve the skin's natural elasticity. Its high amino acid content improves surface hydration, while larger peptide and protein molecules form a protective film, effectively minimizing transepidermal water loss (TEWL). It also upregulates Type I collagen production and accelerates the expression of key moisturizing proteins like ceramide synthase (CERS3), filaggrin (FLG), transglutaminase 1 (TGM1), and kallikrein 7 (KLK7). Furthermore, it inhibits collagen-degrading enzymes (e.g., MMP-2, MMP-9) and promotes tissue inhibitors (TIMP-1, TIMP-2), enhancing collagen integrity.
Research
Clinical Evidence
High confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Water-soluble, peptide-enriched hydrolyzed and fermented placenta powder formulations have been developed and reported to exhibit good stability.
Safety
Safety Profile
EWG Skin Deep assesses 'Hydrolyzed Placental Extract' with low concerns regarding cancer, allergies & immunotoxicity, and developmental & reproductive toxicity. Products containing this ingredient are allowed within EWG VERIFIED™ criteria subject to specific usage restrictions and contamination limits. A safety evaluation of a fermented, peptide-enriched hydrolyzed swine placenta extract powder indicated an acute oral LD50 greater than 5000 mg/kg body weight in rats, with no mutagenic potential observed in standard assays. A 28-day oral toxicity study showed no adverse effects at doses up to 1000 mg/kg, establishing a No Observed Adverse Effect Level (NOAEL) greater than 1000 mg/kg body weight. Its safety has been certified by the Japanese Institute for Health Food Standards (JIHFS).
Your Skin
Skin Compatibility
Our Assessment
Verdict
Hydrolyzed Pig Placenta Extract is a valuable multi-functional ingredient demonstrating significant efficacy in enhancing skin hydration, elasticity, and reducing wrinkles, supported by a favorable safety profile.
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