Science
Mechanism of Action
This extract actively works by reducing intracellular reactive oxygen species (ROS) and enhancing the skin's endogenous DNA repair processes, particularly following UVB exposure. It stimulates keratinocyte proliferation and modulates cell cycle checkpoint proteins, contributing to cellular regeneration. Beyond these restorative actions, the extract exhibits broad antioxidant, anti-inflammatory, and anti-allergic effects, mitigating oxidative stress and inflammatory responses. Crucially, it upregulates hyaluronan synthase enzymes (HAS2 and HAS3), thereby boosting dermal hydration and assisting in the structural restoration of the skin barrier.
Research
Clinical Evidence
Medium confidence0.1%
Key findings
- 01 An in vivo investigation utilized a 0.1% w/w formulation of a related hydrolyzed Perilla frutescens cell-derived phytocomplex, demonstrating its capacity to regulate the keratinocyte inflammatory cascade, enhance barrier function, and maintain mucosal integrity.
Transparency
Dusting Analysis
No specific data regarding dusting thresholds or common dusting practices for Hydrolyzed Perilla Ocymoides Callus Extract is available within the provided research.
The Formula
Formulation
Stability
The hydrolyzed nature of the extract generally confers improved water solubility. While a specific optimal pH range for stability has not been explicitly determined, a related culture medium was maintained at pH 6.5. It is important to note that anthocyanins, which can be active components within Perilla extracts, are susceptible to degradation at elevated pH levels, suggesting a preference for formulations within a slightly acidic to neutral pH range.
Safety
Safety Profile
Formal safety assessments by CIR (Cosmetic Ingredient Review) or SCCS (Scientific Committee on Consumer Safety) for Hydrolyzed Perilla Ocymoides Callus Extract or its closely related INCI names are currently unavailable. The Good Scents Company reports 'None found' for GHS classification, hazard statements, and precautionary statements for 'Perilla Frutescens Callus Culture Extract', with oral, dermal, and inhalation toxicity listed as 'Not determined'. The FDA status is not specifically reviewed, which typically results in a CIR classification of 'No Reported Uses' or 'Insufficient Data or Information' if not in common use.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This ingredient presents as a valuable active due to its demonstrated in vivo efficacy at 0.1% in barrier enhancement and inflammation regulation, coupled with robust mechanistic data supporting its antioxidant and hydrating capabilities, making it suitable for a broad range of skin types despite some gaps in formal safety reviews.
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References
Sources