Science
Mechanism of Action
Hydrolyzed Metschnikowia Agaves Extract precisely targets and reactivates the skin's intrinsic hyaluronic acid (HA) production mechanisms. It achieves this by notably increasing the expression of the hyaluronan synthase (HAS2) enzyme, which is crucial for synthesizing endogenous HA. This action helps to counteract the age-related decline in natural HA, thereby restoring vital moisture, improving skin architecture, and diminishing the appearance of lines and wrinkles.
Research
Clinical Evidence
Medium confidence2%
Key findings
- 01 In vitro studies demonstrated a remarkable 651% increase in hyaluronan synthase (HAS2) expression and a 237% boost in the synthesis of hyaluronic acid itself.
- 02 Clinical in vivo trials, utilizing a 2% concentration twice daily for 28 days, significantly smoothed skin microrelief at the crow's feet area, reducing roughness parameters Sq and Sa by 6.3% and 7.1% respectively.
- 03 Further in vivo research, conducted with 2% concentration applied twice daily over 28 days, confirmed a 14.2% reduction in wrinkles' volume in 70% of volunteer participants.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that Metschnikowia Agaves Extract, a yeast-derived ingredient, is safe for use in cosmetic formulations. Based on 2023 US FDA VCRP survey data, it is typically incorporated into products at concentrations up to 2%.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Hydrolyzed Metschnikowia Agaves Extract presents as a valuable ingredient for advanced skincare, demonstrating robust clinical efficacy in boosting skin's endogenous hyaluronic acid synthesis, leading to improved hydration and notable wrinkle reduction.
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References
Sources