Science
Mechanism of Action
This extract operates through a multi-pronged mechanism, leveraging its wealth of polysaccharides, triterpenes (like inotodiol and betulinic acid), melanin, and phenolic compounds. It functions as a powerful antioxidant, diligently neutralizing free radicals and mitigating oxidative stress to protect skin cells. Its anti-inflammatory properties help to reduce redness and irritation by modulating the secretion of inflammatory proteins by keratinocytes. Furthermore, specific triterpenoids can modify gene expression, enhancing the synthesis of essential structural components such as collagen, elastin, and hyaluronic acid, while simultaneously inhibiting enzymes responsible for their degradation. This integrated action supports skin regeneration, fortifies the skin's protective barrier, improves elasticity, and refines texture, contributing to increased epidermal volume and overall smoothness.
Research
Clinical Evidence
High confidence0.5%
Key findings
- 01 Topical application of a 0.5% concentration in a water-based cosmetic composition resulted in significant improvements across multiple skin parameters, including texture, radiance, reduction in fine lines and wrinkles, improved hydration, reduced hyperpigmentation, and enhanced smoothness, as reported by 30 individuals after 10 days.
- 02 In human fibroblast cells, a 0.0025% concentration demonstrated a 33% reduction in intracellular reactive oxygen species (ROS) and a 26% inhibition of hydrogen peroxide-induced apoptosis and premature cell aging, leading to an increase in cell viability from 48.4% to 69.5%.
- 03 Inotodiol, a key triterpenoid from Chaga, at concentrations up to 0.002% (20 μg/mL), was non-toxic to human keratinocytes. It was also shown to reduce inflammation induced by UVB and TNF-α and upregulate genes associated with hyaluronan and collagen synthesis.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Optimal pH for cosmetic formulations containing Chaga extract typically ranges from 5.0 to 8.0, with a more precise ideal range noted between 6.0 and 7.0. The extract is predominantly water-soluble, though certain triterpenes within it exhibit alcohol solubility.
Safety
Safety Profile
The ingredient is generally well-tolerated and described as non-toxic, with virtually no contraindications for topical applications. In vitro studies specifically noted that inotodiol, a key component, was non-toxic to human keratinocytes below 20 µg/mL.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Hydrolyzed Inonotus Obliquus Extract is a valuable, multi-functional ingredient that demonstrates significant clinical efficacy in improving skin texture, radiance, and overall youthfulness, while offering robust antioxidant and anti-inflammatory protection suitable for all skin types.
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