Science
Mechanism of Action
This ingredient is believed to exert anti-inflammatory effects by inhibiting the enzyme 11β-HSD2, which raises local cortisol levels and reduces pro-inflammatory cytokines. It also acts as an antioxidant by scavenging free radicals and may brighten skin by inhibiting tyrosinase.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
There is no information to suggest this ingredient is commonly used at ineffective concentrations in formulations.
The Formula
Formulation
Stability
Glycyrrhizin derivatives exhibit high stability between pH 4.5 and 9.5. However, stability may decrease at pH values above 6, and gelling can occur below pH 4.
Safety
Safety Profile
Related glycyrrhizinate compounds are deemed safe by the CIR Expert Panel, showing no significant irritancy or sensitization. Ammonium Glycyrrhizinate is affirmed as GRAS by the US FDA.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Hydrolyzed Glycyrrhizinate is a valuable ingredient with a strong safety profile and broad skin compatibility, offering soothing, brightening, and antioxidant benefits based on its established mechanism and related compounds.
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