Science
Mechanism of Action
Hydrolyzed Fibronectin (FN) integrates into the skin's extracellular matrix, promoting cell adhesion, migration, and proliferation, which are essential for tissue repair and regeneration. It facilitates the organization of structural proteins like collagen, creating a stable framework for new tissue growth. Its mechanism involves integrin binding, which initiates intracellular signals supporting cell survival and movement, and cytokine regulation, helping to manage inflammation. Specifically, as a humectant, it attracts and retains water in the skin, boosting hydration and preventing dryness. By maintaining the skin's structural barrier and exerting anti-inflammatory effects, it significantly aids in repairing and soothing sensitive skin, while its role in collagen arrangement can improve skin firmness and structure, offering anti-aging benefits.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 A fibronectin-containing serum led to significant improvements in skin hydration (P < 0.01), reduced transepidermal water loss (TEWL) by days 3 (P < 0.05), 7 (P < 0.01), and 28 (P < 0.01), and enhanced skin radiance and erythema reduction by days 7 and 28 (P < 0.01) in a 28-day split-face study involving 32 healthy female participants post-IPL treatment. No adverse events were reported.
- 02 Recombinant human fibronectin (rhFN) products demonstrated a substantial 24.2% reduction in TEWL over a four-week period in individuals with damaged scalps, indicating enhanced skin barrier integrity.
- 03 In murine models, recombinant human fibronectin (rhFNP) accelerated wound healing, reversed epidermal and dermal thickening associated with aging, increased collagen content, and normalized tissue architecture. It also downregulated inflammatory cytokines (IL-1α, IL-1β, IL-18) and matrix metalloproteinases (MMP3, MMP8, MMP9, MMP13), while upregulating barrier repair genes (FLG, LOR, AQP1) and promoting collagen types I and III expression.
Transparency
Dusting Analysis
Hydrolyzed Fibronectin's documented clinical efficacy in improving hydration, barrier function, and supporting wound healing, alongside its significant role in ECM, suggests it is a valuable active ingredient rather than a 'dusted' one.
The Formula
Formulation
Stability
For optimal stability, Hydrolyzed Fibronectin is best formulated in a buffer with a neutral pH, ideally between 7.0 and 7.6. When reconstituted from lyophilized powder, the resulting pH is typically 7.4-7.6. Storage at 2-10 °C is recommended prior to reconstitution, and -20°C after, with strict avoidance of repeated freeze-thaw cycles. Excessive agitation, such as vortexing, should also be avoided.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has deemed Hydrolyzed Fibronectin safe for use in cosmetics under current practices. Clinical studies have consistently reported no adverse events. Information regarding SCCS and FDA status for cosmetic use was not explicitly available in the provided data.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Hydrolyzed Fibronectin is a valuable ingredient, demonstrating significant efficacy in improving skin hydration, barrier integrity, and supporting repair processes, making it highly beneficial for various skin concerns, especially dry and sensitive skin.
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