Science
Mechanism of Action
Hydrolyzed Fibroin functions primarily as a potent humectant, drawing and retaining moisture within the stratum corneum by forming a breathable, semi-permeable film that prevents transepidermal water loss. Its biomimetic amino acid composition facilitates optimal integration with skin proteins, potentially stimulating cellular processes such as collagen synthesis for improved elasticity and firmness. Furthermore, it demonstrates anti-inflammatory bioactivity through dose-dependent inhibition of NF-kB driven gene expression, effectively calming irritated skin and reducing redness. This ingredient is also capable of penetrating the skin's dermis to actively regulate humidity and deliver anti-aging benefits.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Clinical and in vitro studies confirm concentration-dependent moisturizing efficacy at 1-5% w/v, significantly increasing stratum corneum hydration and promoting a soft, smooth skin texture.
- 02 In vitro assays indicate dose-dependent anti-inflammatory effects through inhibition of NF-kB driven gene expression, reducing inflammatory markers like TNF-α and MMP-9.
- 03 Research suggests a role in enhancing skin barrier function and stimulating collagen synthesis.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
This ingredient maintains optimal stability across a pH range of 4.0 to 8.0. Hydrolysis significantly enhances its aqueous solubility and stability by preventing the self-association typical of native fibroin. A high-quality form should be nearly odorless and range from colorless to a pale yellow.
Safety
Safety Profile
The CIR Expert Panel has thoroughly reviewed Hydrolyzed Fibroin and related silk proteins, concluding they are safe for use in cosmetics at current concentrations. Extensive testing, including dermal toxicity, irritation, and sensitization studies, consistently classifies hydrolyzed silk as non-irritating and non-sensitizing, demonstrating high biocompatibility.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Hydrolyzed Fibroin is a highly versatile and biocompatible ingredient that offers significant benefits for hydration, barrier function, and anti-aging, making it a valuable addition to precision skincare formulations.
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