Science
Mechanism of Action
Functioning primarily through its potent Gastrodia Elata components, this ingredient exhibits antioxidant and anti-aging effects by neutralizing reactive oxygen species and interrupting oxidation chain reactions. It activates the Nrf2/ARE signaling pathway, thereby upregulating endogenous antioxidants such as superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). Furthermore, it reduces UV-induced matrix metalloproteinase (MMPs) production, safeguarding dermal collagen and elastin fibers to effectively delay wrinkle formation. Its anti-inflammatory and soothing properties stem from inhibiting the excessive expression of cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2), along with a reduction in pro-inflammatory cytokines like interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha). This action effectively alleviates redness and itching, enhancing overall skin barrier function, particularly beneficial for sensitive conditions like atopic dermatitis. Moreover, intrinsic polysaccharides and amino acids create a hydrophilic film on the skin's surface, reducing transepidermal water loss (TEWL) and boosting hydration. These elements also penetrate the stratum corneum to bind natural moisturizing factors and modulate filaggrin expressions. Skin brightening is achieved by inhibiting melanin synthesis through the suppression of tyrosinase activity and by reducing mRNA and protein expression of MITF, tyrosinase, Trp1, and Trp2.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 At a concentration of 2 mg/mL, this ingredient demonstrated significant inhibition of elastase activity in human dermal fibroblast cells after UVA exposure.
- 02 In human dermal fibroblast cells, 5 mg/mL showed considerable free radical scavenging, with 31-44% activity against DPPH and ABTS radicals.
- 03 Increasing the concentration to 10 mg/mL maintained 31-44% DPPH and ABTS radical scavenging activities and initiated a 57% increase in superoxide dismutase activity in human dermal fibroblast cells.
- 04 A concentration of 25 mg/mL further enhanced superoxide dismutase activity to a robust 76% in human dermal fibroblast cells.
- 05 Studies indicate that lower doses effectively inhibit melanin synthesis by suppressing tyrosinase activity.
- 06 Higher doses achieved melanin synthesis inhibition levels comparable to the well-known brightening agent, arbutin.
Transparency
Dusting Analysis
No specific data for dusting analysis or optimal product percentage ranges were identified for this ingredient. Clinical efficacy is reported in mg/mL concentrations, which prevents direct correlation to percentage-based dusting thresholds.
The Formula
Formulation
Stability
No specific data regarding optimal pH or stability parameters were found in the available research.
Safety
Safety Profile
While the precise ingredient HYDROLYZED CYCLIZED (GASTRODIA ELATA ROOT/STEM EXTRACT/AMYLODEXTRIN) has not been reviewed by CIR or SCCS, its core component, Gastrodia Elata Root Extract, is generally recognized as a safe cosmetic ingredient for skin conditioning. It lacks GHS classification, hazard statements, or precautionary statements concerning oral, dermal, or inhalation toxicity according to The Good Scents Company. The EWG Skin Deep database rates Gastrodia Elata Root Extract as 'Low' for potential concerns such as cancer, allergies, immunotoxicity, and developmental toxicity, although data availability is noted as 'None' in some categories. Furthermore, Gastrodia Elata is classified as a food-grade ingredient by the Ministry of Food and Drug Safety of Korea, and a combination extract has been approved as a functional food ingredient with no reported human adverse events.
Your Skin
Skin Compatibility
Our Assessment
Verdict
HYDROLYZED CYCLIZED (GASTRODIA ELATA ROOT/STEM EXTRACT/AMYLODEXTRIN) is a highly valuable, multi-functional ingredient, clinically demonstrated to deliver significant antioxidant, anti-aging, anti-inflammatory, brightening, and moisturizing benefits with an excellent safety and compatibility profile suitable for all skin types.
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References
Sources