Science
Mechanism of Action
This extract is hypothesized to modulate skin responses through several pathways. Its anti-inflammatory action may involve suppressing the PDGFRB-mediated PI3K-AKT-mTOR pathway, leading to a reduction in pro-inflammatory mediators such as iNOS, COX-2, IL-1β, and IL-6. Additionally, it could enhance anti-inflammatory microRNA (miR-132) expression. The essential oil component has demonstrated inhibition of nitric oxide (NO) and reactive oxygen species (ROS) production, alongside downregulating pro-inflammatory cytokines, possibly via the ERK protein in the MAPK pathway and IκBα in the NF-κB pathway. Furthermore, it supports the NRF2/HO-1 antioxidant pathway, enhancing cellular defense against oxidative stress.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 An animal study indicated a reduction in inflammatory response within paw biopsies following a 10 mg/kg dosage.
- 02 In vitro, the essential oil of Crossostephium chinense exhibited significant anti-inflammatory effects on RAW264.7 macrophages with an IC50 of 10.3 μg/mL, effectively inhibiting the production of nitric oxide and reactive oxygen species, and reducing pro-inflammatory cytokines (TNF-α, IL-6, IL-1β).
- 03 Ethanolic and aqueous extracts have demonstrated dose-dependent antioxidant and antiproliferative activities in vitro.
Transparency
Dusting Analysis
Insufficient data available to determine dusting propensity or thresholds for cosmetic applications.
The Formula
Formulation
Stability
The hydrolyzed nature of the extract typically enhances water solubility, making it suitable for aqueous formulations. Extraction methods involving water and ethanol suggest good compatibility with polar solvents.
Safety
Safety Profile
No specific safety assessments for HYDROLYZED CROSSOSTEPHIUM CHINENSE EXTRACT have been identified from regulatory bodies such as CIR, SCCS, or FDA. Further evaluation is necessary to establish comprehensive safety parameters for cosmetic use.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Hydrolyzed Crossostephium Chinense Extract presents valuable potential for precision skincare formulations due to its promising anti-inflammatory and antioxidant activities observed in in-vitro and animal studies. However, additional human clinical data specific to cosmetic applications and formal safety evaluations are required for comprehensive characterization.
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References
Sources