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HYDROLYZED COW PLACENTA EXTRACT.

Valuable / SKIN CONDITIONING

Hydrolyzed Cow Placenta Extract is a sophisticated protein hydrolysate, rich in amino acids, peptides, and proteins, designed as a multifaceted ingredient for advanced skincare and hair formulations. It delivers comprehensive benefits spanning potent antioxidant protection, enhanced hydration, and robust support for dermal collagen integrity, alongside promoting hair health.

Summary

Antistatic Hair conditioning Skin conditioning Moisturizing Nourishing Regenerating Film-forming Protecting Restructuring Improves surface hydration Improves elasticity Reduces trans-epidermal-water-loss (TEWL) Helps with wound healing Anti-inflammatory Helps with collagen production Improves skin firmness Helps with barrier repair and protection Helps with hair thickness and hair growth Antioxidant

Science

Mechanism of Action

This extract functions as a powerful antioxidant by directly scavenging free radicals and significantly increasing the activity of key endogenous antioxidant enzymes such as catalase (CAT), glutathione peroxidase (GSH-Px), peroxidase (POD), and superoxide dismutase (SOD), while concurrently reducing oxidative stress markers like malondialdehyde (MDA). Its anti-inflammatory properties contribute to skin calming. Structurally, it promotes dermal integrity by decreasing the expression of collagen-degrading matrix metalloproteinases (MMP-1a and MMP-3) and boosting collagen synthesis through increased expression of transforming growth factor-β (TGF-β) and tissue inhibitor of metalloproteinase 1 (TIMP-1). The amino acid profile improves surface hydration and elasticity, while larger peptides form a protective film to minimize transepidermal water loss (TEWL). Furthermore, its content of growth factors and cytokines supports barrier repair and accelerates wound healing via cell proliferation, inflammation modulation, and angiogenesis.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A clinical trial involving women with androgenetic alopecia observed that a cow placenta hair tonic lotion was as effective as minoxidil 2% over six months, leading to increased hair growth.
  2. 02 In an in vivo mouse model, oral administration of 1500 mg/kg/day cow placenta extract demonstrated a protective effect against D-galactose-induced skin aging, evidenced by enhanced antioxidant enzyme activity, reduced oxidative stress, and modulated expression of collagen-related enzymes (decreased MMP-1a/3, increased TGF-β/TIMP-1).

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While HYDROLYZED COW PLACENTA EXTRACT specifically has not undergone a distinct CIR or SCCS safety review, general 'Placental Extracts' are subject to regulatory scrutiny in the EU and US due to potential hormonal content, generally not considered suitable for cosmetics. However, the hydrolysis process is believed to significantly reduce or alter potential hormonal activity by breaking down larger proteins. All cosmetic products containing this ingredient must undergo rigorous safety assessments to ensure consumer safety and address any potential risks, including endocrine disruption.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Hydrolyzed Cow Placenta Extract is a valuable multi-functional ingredient demonstrating strong antioxidant, collagen-boosting, hydrating, and hair growth properties, supported by mechanistic data and a human hair efficacy study, though regulatory caution exists for general placental extracts.

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References

Sources