Science
Mechanism of Action
This extract operates through several mechanisms: it actively inhibits elastase, an enzyme contributing to skin degradation, and significantly reduces MMP-1 expression, which is a key mediator in collagen breakdown. It also suppresses the release of pro-inflammatory cytokines, specifically IL-6 and IL-8, thereby reducing inflammatory responses. Furthermore, it supports skin barrier function by upregulating filaggrin and exhibits antioxidant properties by reducing reactive oxygen species, protecting skin from oxidative stress.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Demonstrated elastase inhibitory activity with an IC50 of 0.457 mg/mL.
- 02 Inhibited MMP-1 expression by up to 61% in UVB-exposed human reconstituted skin.
- 03 Reduced the release of pro-inflammatory cytokines IL-6 by 30% and IL-8 by 57% in a KeraSkin™-FT model.
Transparency
Dusting Analysis
There is no specific data to suggest this ingredient is commonly 'dusted' at ineffective concentrations. Clinical efficacy was observed at specific concentrations in in-vitro/ex-vivo models.
The Formula
Formulation
Safety
Safety Profile
Specific regulatory status by CIR, SCCS, or FDA for 'HYDROLYZED CORNUS WALTERI LEAF EXTRACT' is currently unavailable. General Cornus walteri extract has no reported GHS classification, hazard statements, or determined toxicity according to The Good Scents Company, suggesting a low risk profile.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Hydrolyzed Cornus Walteri Leaf Extract is a valuable botanical offering robust anti-aging, anti-inflammatory, and barrier-strengthening benefits, particularly suitable for sensitive, dry, and photoaged skin due to its clinically observed efficacy and low irritancy.
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References
Sources