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Moumoujus

HYDROLYZED CONCHIOLIN PROTEIN.

Valuable CAS 169590-57-2 / HAIR CONDITIONING, SKIN CONDITIONING

Hydrolyzed Conchiolin Protein (HCP) is a marine-derived peptide complex celebrated for its multifaceted benefits, including significant skin brightening, deep hydration, and regenerative properties. It actively reduces melanin production and supports skin's natural renewal processes, leading to a more radiant and even-toned complexion.

Summary

Moisturizer/Humectant Skin-conditioning agent Skin brightener/Whitening agent Anti-aging agent (through regeneration) Hair-conditioning agent

Science

Mechanism of Action

HCP's efficacy stems from its ability to deliver smaller peptides that penetrate the stratum corneum, reaching deeper epidermal layers. These peptides are instrumental in replenishing structural proteins and stimulating new keratin cell synthesis, thereby enhancing skin regeneration and improving overall structure. As a powerful humectant, HCP attracts and binds moisture within the epidermis, significantly boosting hydration and establishing a protective barrier against transepidermal water loss. Its pronounced anti-melanogenesis properties are attributed to several pathways: it acts as an anti-endothelin antagonist, modulating melanocyte receptor signals; inhibits tyrosinase activity; and decreases melanin production triggered by UVB exposure. Furthermore, HCP antagonizes α-MSH and ET-1 induced effects on melanoma cells, promotes melanosome transfer, and regulates the PKA/cAMP response element-binding (CREB) and MEK/extracellular signaling-regulated kinase (ERK) pathways to suppress melanin synthesis and the expression of related proteins like MITF, tyrosinase, and tyrosinase-related protein-2.

Research

Clinical Evidence

High confidence
Effective range 0.00125–0.02%
Optimal

N/A

Key findings

  1. 01 Exerted a significant whitening effect on MNT-1 human melanoma cells in an MDPI study.
  2. 02 Restrained melanogenesis effectively in vitro and showed an obvious fade-away efficacy of skin chloasma in vivo.
  3. 03 Significantly reduced melanin content in B16F10 cells by 26.1%.
  4. 04 Significantly reduced melanin content in B16F10 cells by 22.6%.
  5. 05 Significantly reduced melanin content in B16F10 cells by 20.4%.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 3 – 9
0 7 14

Stability

Stable, light-resistant, and heat-resistant within its optimal pH range (3.0-9.0). For maintaining bioactivity and integrity long-term, storage between 4°C and 8°C is recommended to prevent degradation, oxidation, and microbial contamination.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Hydrolyzed Conchiolin Protein is generally considered safe for cosmetic use, noted as non-poisonous, non-irritant, and non-allergenic. While not individually reviewed by CIR, broader categories of 'tissue-derived proteins and peptides' and 'hydrolyzed source proteins' have been deemed safe. Some individuals with sensitive skin may experience mild, temporary irritation upon initial use.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Hydrolyzed Conchiolin Protein is a valuable ingredient for its proven ability to significantly brighten skin, reduce hyperpigmentation, and provide substantial hydration and regenerative support, with a low risk of irritation.

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